Fenoldopam hydrochloride, D1-like dopamine receptor partial agonist (ab145955)

Overview

  • Product name

    Fenoldopam hydrochloride, D1-like dopamine receptor partial agonist
  • Description

    Selective D1-like dopamine receptor partial agonist. Vasodilator in vivo. α2-adrenoceptor antagonist in vitro.
  • Alternative names

    • 6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol hydrochloride
    • 6-chloro-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-(1H)-3-benzazepine
    • SK & F82526
    • SK&F82526
    • SKF 82526
    • SKF82526
    see all
  • Purity

    > 95%
  • CAS Number

    181217-39-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-Chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrochloride
  • Molecular weight

    342.22
  • Molecular formula

    C16H16ClNO3.HCl
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Chen Y  et al. Gastrin and D1 dopamine receptor interact to induce natriuresis and diuresis. Hypertension 62:927-33 (2013). Read more (PubMed: 24019399) »
  • Grenader A & Healy DP Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther 258:193-8 (1991). Read more (PubMed: 1677038) »
  • Nichols AJ  et al. The pharmacology of fenoldopam. Am J Hypertens 3:116S-119S (1990). Read more (PubMed: 1974439) »
  • Ohlstein EH  et al. The DA1 receptor agonist fenoldopam (SK & F 82526) is also an alpha 2-adrenoceptor antagonist. Eur J Pharmacol 118:321-9 (1985). Read more (PubMed: 2867915) »
  • Hahn RA  et al. Characterization of the peripheral and central effects of SK&F 82526, a novel dopamine receptor agonist. J Pharmacol Exp Ther 223:305-13 (1982). Read more (PubMed: 6127401) »
  • Sibley DR  et al. Interactions of novel dopaminergic ligands with D-1 and D-2 dopamine receptors. Life Sci 31:637-45 (1982). Read more (PubMed: 6127585) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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