Fenspiride hydrochloride, bronchodilator with anti-inflammatory properties (ab145818)

Overview

  • Product name

    Fenspiride hydrochloride, bronchodilator with anti-inflammatory properties
  • Description

    Bronchodilator with anti-inflammatory properties
  • Alternative names

    • 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride
    • Fenspiride HCl
  • Biological description

    Bronchodilator with anti-inflammatory properties. Inhibits phosphodiesterase 4 and phosphodiesterase 3 activities with log IC50 values of 4.16 and 3.44, respectively, in human isolated bronchi. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenoceptor and H1 histamine receptors.

  • CAS Number

    5053-08-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride
  • Molecular weight

    296.79
  • Molecular formula

    C15H20N2O2.HCl
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM and in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Jankowski R [ENT inflammation and importance of fenspiride]. Presse Med 31 Spec No 1:HS7-10 (2002). Read more (PubMed: 12378970) »
  • Khawaja AM  et al. Effect of fenspiride, a non-steroidal antiinflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro. Pulm Pharmacol Ther 12:363-8 (1999). Read more (PubMed: 10587477) »
  • Cortijo J  et al. Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: functional and biochemical study. Eur J Pharmacol 341:79-86 (1998). Read more (PubMed: 9489859) »
  • Quartulli F  et al. Fenspiride inhibits histamine-induced responses in a lung epithelial cell line. Eur J Pharmacol 348:297-304 (1998). Read more (PubMed: 9652346) »
  • De Castro CM  et al. Fenspiride: an anti-inflammatory drug with potential benefits in the treatment of endotoxemia. Eur J Pharmacol 294:669-76 (1995). Read more (PubMed: 8750732) »
  • Cunha FQ  et al. Blockade by fenspiride of endotoxin-induced neutrophil migration in the rat. Eur J Pharmacol 238:47-52 (1993). Read more (PubMed: 8104802) »

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