Product nameFerrostatin 1, erastin-induced ferroptosis inhibitor
DescriptionPotent, selective erastin-induced ferroptosis inhibitor
Biological descriptionPotent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Lorincz T et al. Ferroptosis is Involved in Acetaminophen Induced Cell Death. Pathol Oncol Res 21:1115-21 (2015). Read more (PubMed: 25962350) »
- Eling N et al. Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience 2:517-32 (2015). Read more (PubMed: 26097885) »
- Liu Y et al. The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis. Biol Pharm Bull 38:1234-9 (2015). Read more (PubMed: 26235588) »