Ferrostatin 1, erastin-induced ferroptosis inhibitor (ab146169)
- Datasheet
- References
Overview
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Product nameFerrostatin 1, erastin-induced ferroptosis inhibitor
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DescriptionPotent, selective erastin-induced ferroptosis inhibitor
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Biological descriptionPotent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level.
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CAS Number347174-05-4
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Chemical structure
Properties
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Molecular weight262.35
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Molecular formulaC15H22N2O2
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Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
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Solubility overview
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILESO=C(OCC)c2ccc(NC1CCCCC1)c(N)c2
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Source
Synthetic
References
This product has been referenced in:
- Lorincz T et al. Ferroptosis is Involved in Acetaminophen Induced Cell Death. Pathol Oncol Res 21:1115-21 (2015). Read more (PubMed: 25962350) »
- Eling N et al. Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience 2:517-32 (2015). Read more (PubMed: 26097885) »
- Liu Y et al. The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis. Biol Pharm Bull 38:1234-9 (2015). Read more (PubMed: 26235588) »
