Ferrostatin 1, erastin-induced ferroptosis inhibitor (ab146169)

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Chemical Structure - Ferrostatin 1, erastin-induced ferroptosis inhibitor (ab146169)

    Key features and details

    • Potent, selective erastin-induced ferroptosis inhibitor
    • CAS Number: 347174-05-4

    • Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).

    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Ferrostatin 1, erastin-induced ferroptosis inhibitor

    • Description

      Potent, selective erastin-induced ferroptosis inhibitor

    • Biological description

      Potent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level.

    • CAS Number

      347174-05-4

    • Chemical structure

      Chemical Structure

    Properties

    • Molecular weight

      262.35

    • Molecular formula

      C15H22N2O2

    • Storage instructions

      Store at Room Temperature. The product can be stored for up to 12 months.

    • Solubility overview

      Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).

    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      O=C(OCC)c2ccc(NC1CCCCC1)c(N)c2

    • Source

      Synthetic

    Associated products

      Images

      • Chemical Structure - Ferrostatin 1, erastin-induced ferroptosis inhibitor (ab146169)
        Chemical Structure - Ferrostatin 1, erastin-induced ferroptosis inhibitor (ab146169)
        2D chemical structure image of ab146169, Ferrostatin 1, erastin-induced ferroptosis inhibitor

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      References (1)

      Publishing research using ab146169? Please let us know so that we can cite the reference in this datasheet.

      ab146169 has been referenced in 1 publication.

      • Wenzel SE  et al. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell 171:628-641.e26 (2017). PubMed: 29053969

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