Ferrostatin 1, erastin-induced ferroptosis inhibitor (ab146169)
Key features and details
- Potent, selective erastin-induced ferroptosis inhibitor
- CAS Number: 347174-05-4
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ferrostatin 1, erastin-induced ferroptosis inhibitor -
Description
Potent, selective erastin-induced ferroptosis inhibitor -
Biological description
Potent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level. -
CAS Number
347174-05-4 -
Chemical structure
Properties
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Molecular weight
262.35 -
Molecular formula
C15H22N2O2 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(OCC)c2ccc(NC1CCCCC1)c(N)c2 -
Source
Synthetic
Images
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Chemical Structure - Ferrostatin 1, erastin-induced ferroptosis inhibitor (ab146169)2D chemical structure image of ab146169, Ferrostatin 1, erastin-induced ferroptosis inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab146169 has been referenced in 1 publication.
- Wenzel SE et al. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell 171:628-641.e26 (2017). PubMed: 29053969