Overview

  • Product name

    Ferulenol, ATP synthesis inhibitor
  • Description

    ATP synthesis inhibitor. Potent antibiotic agent. Tubulin polymerisation stimulator.
  • Biological description

    ATP synthesis inhibitor. Potent antibiotic agent. Tubulin polymerization stimulator. Selective succinate ubiquinone reductase inhibitor. Induces mPTP opening and disrupts mitochondrial membrane potential. Shows cytotoxic effects against cancer cell lines. Shows more potent anticoagulant activity than warfarin (ab141979) in vivo.
  • Purity

    > 98%
  • CAS Number

    6805-34-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Hydroxy-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one
  • Molecular weight

    366.49
  • Molecular formula

    C24H30O3
  • PubChem identifier

    54679300
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=CCC/C(=C/CC/C(=C/CC1=C(C2=CC=CC=C2OC1=O)O)/C)/C)C
  • Source

    Ferula communis

  • Research areas

References

This product has been referenced in:

  • Nadia BH  et al. Disruption of mitochondrial membrane potential by ferulenol and restoration by propolis extract: antiapoptotic role of propolis. Acta Biol Hung 60:385-98 (2009). Read more (PubMed: 20015830) »
  • Lahouel M  et al. Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle. Biochem Biophys Res Commun 355:252-7 (2007). Read more (PubMed: 17292330) »
  • Monti M  et al. Characterization of anti-coagulant properties of prenylated coumarin ferulenol. Biochim Biophys Acta 1770:1437-40 (2007). Read more (PubMed: 17693024) »

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