Overview

  • Product name

    Ferutinin, ERalpha agonist
  • Description

    Potent ERα agonist and ERβ agonist / antagonist
  • Biological description

    Potent ERα agonist and ERβ agonist / antagonist (IC50 values are 33 and 181 nM for ERα and ERβ respectively). Increases calcium permeability in the lipid bilayer. Induces apoptosis. Shows selective cytotoxic effects to tumor cells. Shows chemopreventive and anticancer effects in vivo.
  • Purity

    > 98%
  • CAS Number

    41743-44-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(3R,3aS,4S,8aR)-3-Hydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl] 4-hydroxybenzoate
  • Molecular weight

    358.47
  • Molecular formula

    C22H30O4
  • PubChem identifier

    354654
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC[C@]2(CC[C@]([C@@H]2[C@H](C1)OC(=O)C3=CC=C(C=C3)O)(C(C)C)O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ferretti M  et al. Ferutinin dose-dependent effects on uterus and mammary gland in ovariectomized rats. Histol Histopathol 29:1027-37 (2014). Read more (PubMed: 24510547) »
  • Matin MM  et al. Ferutinin, an apoptosis inducing terpenoid from Ferula ovina. Asian Pac J Cancer Prev 15:2123-8 (2014). Read more (PubMed: 24716944) »
  • Arghiani N  et al. Investigating anticancer properties of the sesquiterpene ferutinin on colon carcinoma cells, in vitro and in vivo. Life Sci 109:87-94 (2014). Read more (PubMed: 24953605) »
  • Ikeda K  et al. Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta. Biochem Biophys Res Commun 291:354-60 (2002). Read more (PubMed: 11846412) »

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