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    fetal-hemoglobin-antibody-ab19364.pdf

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Cardiovascular Blood Serum Proteins
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Anti-fetal hemoglobin antibody (ab19364)

  • Datasheet
  • SDS
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Key features and details

  • Sheep polyclonal to fetal hemoglobin
  • Reacts with: Human
  • Isotype: IgG

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Overview

  • Product name

    Anti-fetal hemoglobin antibody
    See all fetal hemoglobin primary antibodies
  • Description

    Sheep polyclonal to fetal hemoglobin
  • Host species

    Sheep
  • Specificity

    By immunoelectrophoresis and ELISA this antibody reacts specifically with human hemoglobin F. No antibody was detected against hemoglobin A1, A2, S or human serum proteins.
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla
  • Immunogen

    Human Hemoglobin F

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 6.8
    Preservative: 0.1% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    The antibody was isolated by affinity chromato-graphy using antigen coupled to agarose beads. Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cardiovascular
    • Blood
    • Serum Proteins
    • Cardiovascular
    • Blood
    • Other

Associated products

  • Isotype control

    • Sheep IgG - Isotype Control (ab37385)

Target

  • Relevance

    The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'
  • Cellular localization

    Cytoplasmic
  • Database links

    • Entrez Gene: 3047 Human
    • Entrez Gene: 3048 Human
    • Omim: 142200 Human
    • Omim: 142250 Human
    • SwissProt: P69891 Human
    • SwissProt: P69892 Human
    • Unigene: 302145 Human
    • Unigene: 702189 Human
    • Alternative names

      • A gamma globin antibody
      • G gamma globin antibody
      • Gamma 1 globin antibody
      • Gamma 2 globin antibody
      • Gamma A hemoglobin antibody
      • Gamma globin antibody
      • Hb F Agamma antibody
      • Hb F Ggamma antibody
      • hbfagamma antibody
      • hbfggamma antibody
      • HBG 1 antibody
      • HBG 2 antibody
      • HBG1 antibody
      • HBG2 antibody
      • HBGA antibody
      • HBGR antibody
      • Hemoglobin gamma 1 chain antibody
      • Hemoglobin gamma 2 chain antibody
      • Hemoglobin gamma A antibody
      • Hemoglobin gamma A chain antibody
      • Hemoglobin gamma G antibody
      • Hemoglobin gamma G chain antibody
      • Hemoglobin gamma regulator of antibody
      • Hemoglobin subunit gamma 1 antibody
      • Hemoglobin subunit gamma 2 antibody
      • HSGGL 1 antibody
      • HSGGL1 antibody
      • Methemoglobin antibody
      • PRO 2979 antibody
      • PRO2979 antibody
      see all

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (4)

    Publishing research using ab19364? Please let us know so that we can cite the reference in this datasheet.

    ab19364 has been referenced in 4 publications.

    • Wolk M & Martin JE Fetal haemopoiesis marking low-grade urinary bladder cancer. Br J Cancer 107:477-81 (2012). PubMed: 22735903
    • Wolk M & Martin JE Fetal haemoglobin (HbF) as an immunohistochemical tumour marker in bone marrow and spleen. J Clin Pathol 64:645-7 (2011). IHC-P ; Human . PubMed: 21378008
    • Yang M  et al. Effects of Astragalus polysaccharide on the erythroid lineage and microarray analysis in K562 cells. J Ethnopharmacol 127:242-50 (2010). WB . PubMed: 19922785
    • Zhang X  et al. In vitro maturation of erythroid progenitors from human umbilical cord blood and patterns of globin gene expression: serum from different developmental stage plays important roles in liquid culture. Biochem Biophys Res Commun 336:42-8 (2005). PubMed: 16125140

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