Overview

  • Product name
    FeTPPS, peroxynitrite decomposition catalyst and scavenger
  • Description
    Selective peroxynitrite decomposition catalyst and scavenger
  • Biological description
    Selective peroxynitrite decomposition catalyst and scavenger (EC50 = 5 μM). Active in vivo and in vitro.
  • Purity
    > 95%
  • CAS Number
    90384-82-0
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    5,10,15,20-Tetrakis(4-sulfonatophenyl)-21H,23H-porphyrin iron (III) chloride
  • Molecular weight
    1024.27
  • Molecular formula
    Fe(C44H28N4O12S4)Cl
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    O=S(=O)(O)c1ccc(cc1)c8c4C=CC3=C(C2=NC(C=C2)=C(c5ccc(n5[Fe+]n34)c(c6ccc(cc6)S(=O)(=O)O)c7C=Cc8n7)c9ccc(cc9)S(=O)(=O)O)c%10ccc(cc%10)S(=O)(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Klassen SS & Rabkin SW The metalloporphyrin FeTPPS but not by cyclosporin A antagonizes the interaction of peroxynitrate and hydrogen peroxide on cardiomyocyte cell death. Naunyn Schmiedebergs Arch Pharmacol 379:149-61 (2009). Read more (PubMed: 18773197) »
  • Lauzier B  et al. A peroxynitrite decomposition catalyst: FeTPPS confers cardioprotection during reperfusion after cardioplegic arrest in a working isolated rat heart model. Fundam Clin Pharmacol 21:173-80 (2007). Read more (PubMed: 17391290) »
  • Misko TP  et al. Characterization of the cytoprotective action of peroxynitrite decomposition catalysts. J Biol Chem 273:15646-53 (1998). Read more (PubMed: 9624158) »
See 1 Publication for this product

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