Overview

  • Product name

  • Description

    Rabbit polyclonal to FFAR3/GPR41
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human FFAR3/GPR41 aa 286-343.
    Sequence:

    DFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGC GTGGQVAC


    Database link: O14843

  • Positive control

    • IHC-P: Human small intestine tissue.
  • General notes

     This product was previously labelled as FFAR3

     

Properties

Applications

Our Abpromise guarantee covers the use of ab224568 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5-trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate.
  • Tissue specificity

    Highest level in adipose tissue, and lower expression across all tissues tested.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • FFA3R antibody
    • Ffar3 antibody
    • FFAR3_HUMAN antibody
    • Free fatty acid receptor 3 antibody
    • G protein coupled receptor 41 antibody
    • G-protein coupled receptor 41 antibody
    • gpcr41 antibody
    • GPR41 antibody
    • gpr42 antibody
    see all

Images

  • Paraffin-embedded human small intestine tissue stained for FFAR3/GPR41 using ab224568 at 1/500 dilution in immunohistochemical analysis.

References

ab224568 has not yet been referenced specifically in any publications.

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