Overview

  • Product name

    Anti-FGD1 antibody - C-terminal
    See all FGD1 primary antibodies
  • Description

    Rabbit polyclonal to FGD1 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment within Human FGD1 (C terminal). The exact sequence is proprietary.
    Database link: P98174

  • Positive control

    • WB: U-87 MG, SK-N-SH, IMR32 and SK-N-AS whole cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab227302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 106 kDa.

Target

  • Function

    Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
  • Tissue specificity

    Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.
  • Involvement in disease

    Aarskog-Scott syndrome
    Defects in FGD1 are found in a patient with non-syndromal X-linked mental retardation.
  • Sequence similarities

    Contains 1 DH (DBL-homology) domain.
    Contains 1 FYVE-type zinc finger.
    Contains 2 PH domains.
  • Domain

    The DH domain is involved in interaction with CCPG1.
  • Cellular localization

    Cytoplasm. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Associated with membrane ruffles and lamellipodia.
  • Information by UniProt
  • Database links

  • Alternative names

    • AAS antibody
    • Faciogenital dysplasia 1 protein antibody
    • FGD1 antibody
    • FGD1_HUMAN antibody
    • FGDY antibody
    • FYVE RhoGEF and PH domain containing protein 1 antibody
    • FYVE, RhoGEF and PH domain-containing protein 1 antibody
    • Rho/Rac GEF antibody
    • Rho/Rac guanine nucleotide exchange factor FGD1 antibody
    • ZFYVE3 antibody
    • Zinc finger FYVE domain containing protein 3 antibody
    • Zinc finger FYVE domain-containing protein 3 antibody
    see all

Images

  • All lanes : Anti-FGD1 antibody - C-terminal (ab227302) at 1/500 dilution

    Lane 1 : U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell extract
    Lane 2 : SK-N-SH (human neuroblastoma cell line) whole cell extract
    Lane 3 : IMR32 (human brain neuroblast cell line) whole cell extract
    Lane 4 : SK-N-AS (human brain neuroblastoma cell line) whole cell extract

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 106 kDa



    7.5% SDS-PAGE gel.

References

ab227302 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab227302.
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