Product nameAnti-FGD1 antibody - C-terminal
See all FGD1 primary antibodies
DescriptionRabbit polyclonal to FGD1 - C-terminal
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow
Recombinant fragment within Human FGD1 (C terminal). The exact sequence is proprietary.
Database link: P98174
- WB: U-87 MG, SK-N-SH, IMR32 and SK-N-AS whole cell extracts.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab227302 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 106 kDa.|
FunctionActivates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
Tissue specificityExpressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.
Involvement in diseaseAarskog-Scott syndrome
Defects in FGD1 are found in a patient with non-syndromal X-linked mental retardation.
Sequence similaritiesContains 1 DH (DBL-homology) domain.
Contains 1 FYVE-type zinc finger.
Contains 2 PH domains.
DomainThe DH domain is involved in interaction with CCPG1.
Cellular localizationCytoplasm. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Associated with membrane ruffles and lamellipodia.
- Information by UniProt
- AAS antibody
- Faciogenital dysplasia 1 protein antibody
- FGD1 antibody
All lanes : Anti-FGD1 antibody - C-terminal (ab227302) at 1/500 dilution
Lane 1 : U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell extract
Lane 2 : SK-N-SH (human neuroblastoma cell line) whole cell extract
Lane 3 : IMR32 (human brain neuroblast cell line) whole cell extract
Lane 4 : SK-N-AS (human brain neuroblastoma cell line) whole cell extract
Lysates/proteins at 30 µg per lane.
Predicted band size: 106 kDa
7.5% SDS-PAGE gel.
ab227302 has not yet been referenced specifically in any publications.