Overview

  • Product name

  • Description

    Rabbit polyclonal to FGF8
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC - Wholemountmore details
  • Species reactivity

    Reacts with: Zebrafish
  • Immunogen

    Recombinant fragment within Zebrafish FGF8 aa 65-210. The exact sequence is proprietary.
    Database link: O57341

  • Positive control

    • Zebrafish embryo.

Properties

Applications

Our Abpromise guarantee covers the use of ab209991 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC - Wholemount 1/100 - 1/500.

Target

  • Function

    Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells.
  • Involvement in disease

    Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
    Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
  • Sequence similarities

    Belongs to the heparin-binding growth factors family.
  • Developmental stage

    In adults expression is restricted to the gonads.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Alternative names

    • AIGF antibody
    • Androgen induced growth factor antibody
    • Androgen-induced growth factor antibody
    • FGF 8 antibody
    • FGF-8 antibody
    • FGF-8b antibody
    • FGF8 antibody
    • FGF8_HUMAN antibody
    • Fibroblast growth factor 8 (androgen induced) antibody
    • Fibroblast growth factor 8 antibody
    • Fibroblast growth factor 8 precursor antibody
    • HBGF 8 antibody
    • HBGF-8 antibody
    • HBGF8 antibody
    • Heparin-binding growth factor 8 antibody
    • HH6 antibody
    • KAL6 antibody
    see all

Images

  • Whole mount Immunohistochemical analysis of paraformaldehyde-fixed Zebrafish embryos labeling FGF8 with ab209991 at 1/200 dilution.

References

ab209991 has not yet been referenced specifically in any publications.

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