Overview

  • Product name

    Anti-FGFR1 Oncogene Partner antibody
    See all FGFR1 Oncogene Partner primary antibodies
  • Description

    Rabbit polyclonal to FGFR1 Oncogene Partner
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human FGFR1OP-FGFR1 (internal sequence). The exact sequence is proprietary.
    Database link: O95684

  • Positive control

    • WB: Raji whole cell lysate. IHC-P: Human lung cancer tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab229012 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 43 kDa.

Target

  • Function

    Required for anchoring microtubules to the centrosomes.
  • Tissue specificity

    Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.
  • Involvement in disease

    Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
  • Sequence similarities

    Belongs to the FGFR1OP family.
    Contains 1 LisH domain.
  • Cellular localization

    Cytoplasm > cytoskeleton > centrosome. Associated with gamma-tubulin.
  • Information by UniProt
  • Database links

  • Alternative names

    • FGFR1 oncogene partner antibody
    • FGFR1OP antibody
    • Fibroblast growth factor receptor 1 oncogene partner antibody
    • FOP antibody
    • FR1OP_HUMAN antibody
    • OTTHUMP00000017612 antibody
    • OTTHUMP00000017613 antibody
    see all

Images

  • Anti-FGFR1 Oncogene Partner antibody (ab229012) at 1/1000 dilution + Raji (human Burkitt's lymphoma cell line) whole cell lysate at 30 µg

    Predicted band size: 43 kDa



    10% SDS-PAGE gel.

  • Paraffin-embedded human lung cancer tissue stained for FGFR1 Oncogene Partner using ab229012 at 1/500 dilution in immunohistochemical analysis.

References

ab229012 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab229012.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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