Key features and details
- Rabbit polyclonal to FGFR4 (phospho Y642)
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-FGFR4 (phospho Y642) antibody
See all FGFR4 primary antibodies
DescriptionRabbit polyclonal to FGFR4 (phospho Y642)
Specificityab192589 detects endogenous levels of FGFR4 only when phosphorylated at tyrosine 642.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide corresponding to Human FGFR4 (phospho Y642) conjugated to Keyhole Limpet Haemocyanin (KLH). Peptide sequence around phosphorylation site of tyrosine 642 (I-D-Y(p)-Y-K). NP_002002.3
Database link: P22455
- WB: JK cell extracts.
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.87% Sodium chloride, 49% PBS
PBS (without Mg2+and Ca2+)
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab192589 was purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.
Our Abpromise guarantee covers the use of ab192589 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 88 kDa.|
FunctionReceptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.
Tissue specificityExpressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization.
Cellular localizationMembrane. Isoform 2 may be secreted.
- Information by UniProt
- CD 334 antibody
- CD334 antibody
- CD334 antigen antibody
ab192589 has been referenced in 1 publication.
- Zhang X et al. FGF19 genetic amplification as a potential therapeutic target in lung squamous cell carcinomas. Thorac Cancer 8:655-665 (2017). WB . PubMed: 28906590