Anti-Fibrillin 2 antibody (ab128026)

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Overview

  • Product name

    Anti-Fibrillin 2 antibody
    See all Fibrillin 2 primary antibodies

  • Description

    Rabbit polyclonal to Fibrillin 2

  • Host species

    Rabbit

  • Specificity

    No cross-reactivity with Fibrillin 1.

  • Tested applications

    Suitable for: IHC-P, IP, ICC, WB, ELISAmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Cow

  • Immunogen

    Recombinant fragment containing glycine-rich domain of exon 10 of Human Fibrillin 2.

  • Positive control

    • Human Prostate, Extra Cellular tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab128026 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50.
IP 1/100 - 1/200.
ICC 1/50 - 1/100.
WB 1/200 - 1/500. Predicted molecular weight: 315 kDa.
ELISA 1/1000 - 1/2000.

Target

  • Function

    Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.

  • Involvement in disease

    Defects in FBN2 are the cause of congenital contractural arachnodactyly (CCA) [MIM:121050]; also known as Beals syndrome or distal arthrogryposis type 9 (DA9). CCA is a rare, autosomal dominant connective tissue disorder characterized by contractures, arachnodactyly, scoliosis, and crumpled ears. Phenotypically similar to Marfan syndrome, CCA does not affect the aorta and the eyes.

  • Sequence similarities

    Belongs to the fibrillin family.
    Contains 47 EGF-like domains.
    Contains 9 TB (TGF-beta binding) domains.

  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

  • Database links

    • Alternative names

      • CCA antibody
      • congenital contractural arachnodactyly (Marfanoid-like) antibody
      • DA9 antibody
      • FBN2 antibody
      • FBN2_HUMAN antibody
      • fibrillin 2 (congenital contractural arachnodactyly) antibody
      • Fibrillin-2 antibody
      see all

    References

    This product has been referenced in:

    See all 2 Publications for this product

    Publishing research using ab128026? Please let us know so that we can cite the reference in this datasheet.

    Customer reviews and Q&As

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    Question

    Would like to test ab128026 and ab54778 with bovine samples

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    Answer

    DISCOUNT CODE: XXXXXXX

    DISCOUNT CODE: XXXXXXX

    Expiration date: 30-05-2013

    Value: £235 each

    I am very pleased to hear you would like to accept our offer and test ab54778 and ab128026 in Bovine. This code will give you £235 x 2 off your next order before the expiration date. To redeem this offer, please submit an Abreview for Bovine and include this code in the “Additional Comments” section so we know the Abreview is for this promotion. Please remember that submission of the Abreview is sufficient for the discount code to become active.
    For more information on how to submit an Abreview, please visit the site: https://www.abcam.com/Abreviews.

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