• Product name

    Anti-Fibrinogen beta chain antibody
    See all Fibrinogen beta chain primary antibodies
  • Description

    Rabbit polyclonal to Fibrinogen beta chain
  • Host species

  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow, Pig
  • Immunogen

    Recombinant fragment corresponding to Human Fibrinogen beta chain aa 250-491.

  • Positive control

    • 293T, A431, H1299, HeLa, HepG2, MOLT4, Raji and Mouse liver whole cell lysates, HeLa cells



Our Abpromise guarantee covers the use of ab137830 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 56 kDa.
ICC/IF 1/100 - 1/1000.


  • Function

    Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
  • Involvement in disease

    Defects in FGB are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
  • Sequence similarities

    Contains 1 fibrinogen C-terminal domain.
  • Domain

    A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
  • Post-translational

    Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • Beta fibrinogen antibody
    • Epididymis Secretory Sperm Binding Protein Li 78p antibody
    • FGB antibody
    • FIBB_HUMAN antibody
    • Fibrinogen beta chain antibody
    • Fibrinogen, B Beta Polypeptide antibody
    • HEL-S-78p antibody
    see all


  • Anti-Fibrinogen beta chain antibody (ab137830) at 1/5000 dilution + Molt 4 whole cell lysate at 30 µg

    Predicted band size: 56 kDa

    7.5% SDS PAGE
  • Anti-Fibrinogen beta chain antibody (ab137830) at 1/5000 dilution + Mouse liver whole cell lysate at 50 µg

    Predicted band size: 56 kDa

    10% SDS PAGE
  • Immunofluorescence analysis of methanol-fixed HeLa cells, labelling Fibrinogen beta chain using ab137830 at 1/200 dilution. Bottom image is costained with Hoechst 33342.


ab137830 has not yet been referenced specifically in any publications.

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