Anti-Fibroblast activation protein, alpha antibody (ab53066)

Rabbit polyclonal Fibroblast activation protein, alpha antibody. Validated in WB, ELISA, IHC, ICC/IF and tested in Mouse, Dog, Human, Monkey. Cited in 49 publication(s).

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ab53066 has been referenced in 53 publications.

  • Sandberg TP  et al. Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer. BMC Cancer 19:284 (2019). PubMed: 30922247
  • Cao F  et al. Fibroblast activation protein-a in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways. Mol Med Rep 17:2593-2599 (2018). PubMed: 29207091
  • Puré E & Blomberg R Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics. Oncogene 37:4343-4357 (2018). PubMed: 29720723
  • Zhou X  et al. Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway. J Exp Clin Cancer Res 37:242 (2018). PubMed: 30285793
  • Shangguan C  et al. Cancer-associated fibroblasts enhance tumor18F-FDG uptake and contribute to the intratumor heterogeneity of PET-CT. Theranostics 8:1376-1388 (2018). PubMed: 29507627
  • Zeng C  et al. Fibroblast activation protein in osteosarcoma cells promotes angiogenesis via AKT and ERK signaling pathways. Oncol Lett 15:6029-6035 (2018). PubMed: 29552230
  • Wang X  et al. Cancer-associated fibroblasts induce epithelial-mesenchymal transition through secreted cytokines in endometrial cancer cells. Oncol Lett 15:5694-5702 (2018). PubMed: 29563996
  • Kleinerman ES  et al. Aerosol Gemcitabine after Amputation Inhibits Osteosarcoma Lung Metastases but Not Wound Healing. Sarcoma 2018:3143096 (2018). PubMed: 29610563
  • Saito H  et al. Importance of human peritoneal mesothelial cells in the progression, fibrosis, and control of gastric cancer: inhibition of growth and fibrosis by tranilast. Gastric Cancer 21:55-67 (2018). ICC/IF . PubMed: 28540637
  • Liu Y  et al. Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts. Cancer Lett 430:1-10 (2018). PubMed: 29733962
  • Costa A  et al. Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer. Cancer Cell 33:463-479.e10 (2018). IHC-P ; Human . PubMed: 29455927
  • Grinde MT  et al. Ionizing radiation abrogates the pro-tumorigenic capacity of cancer-associated fibroblasts co-implanted in xenografts. Sci Rep 7:46714 (2017). IHC ; Human . PubMed: 28440285
  • Deying W  et al. CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells. Biosci Rep 37:N/A (2017). PubMed: 28258248
  • Du YE  et al. MiR-205/YAP1 in Activated Fibroblasts of Breast Tumor Promotes VEGF-independent Angiogenesis through STAT3 Signaling. Theranostics 7:3972-3988 (2017). PubMed: 29109792
  • Vliegen G  et al. The expression of proline-specific enzymes in the human lung. Ann Transl Med 5:130 (2017). IHC ; Human . PubMed: 28462210
  • Park JI  et al. Scaffold-Free Coculture Spheroids of Human Colonic Adenocarcinoma Cells and Normal Colonic Fibroblasts Promote Tumorigenicity in Nude Mice. Transl Oncol 9:79-88 (2016). IHC-P, ICC/IF ; Human . PubMed: 26947885
  • Tang X  et al. Stromal miR-200s contribute to breast cancer cell invasion through CAF activation and ECM remodeling. Cell Death Differ 23:132-45 (2016). WB, ICC/IF ; Human . PubMed: 26068592
  • Beach JA  et al. Sphingosine kinase 1 is required for TGF-ß mediated fibroblastto- myofibroblast differentiation in ovarian cancer. Oncotarget 7:4167-82 (2016). WB ; Human . PubMed: 26716409
  • Evrard SM  et al. Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability. Nat Commun 7:11853 (2016). WB, IHC-Fr, ICC/IF ; Mouse, Human . PubMed: 27340017
  • Takai K  et al. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget 7:82889-82901 (2016). IHC-P ; Human . PubMed: 27756881
  • Zhu M  et al. miR-155-5p inhibition promotes the transition of bone marrow mesenchymal stem cells to gastric cancer tissue derived MSC-like cells via NF-?B p65 activation. Oncotarget 7:16567-80 (2016). IF . PubMed: 26934326
  • Errarte P  et al. The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases. PLoS One 11:e0169105 (2016). WB, IHC . PubMed: 28033421
  • Laklai H  et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med 22:497-505 (2016). PubMed: 27089513
  • Singhal PK  et al. Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity. Proc Natl Acad Sci U S A 113:122-7 (2016). PubMed: 26699463
  • Clements D  et al. Wild type mesenchymal cells contribute to the lung pathology of lymphangioleiomyomatosis. PLoS One 10:e0126025 (2015). IF ; Human . PubMed: 25978616
  • Liu F  et al. Fibroblast activation protein overexpression and clinical implications in solid tumors: a meta-analysis. PLoS One 10:e0116683 (2015). PubMed: 25775399
  • Zhang M  et al. Expression levels of seprase/FAPa and DPPIV/CD26 in epithelial ovarian carcinoma. Oncol Lett 10:34-42 (2015). PubMed: 26170973
  • Gorchs L  et al. Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation. Front Oncol 5:87 (2015). PubMed: 26029659
  • Kilvaer TK  et al. Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers. PLoS One 10:e0134965 (2015). IHC . PubMed: 26252379
  • Kawase T  et al. Fibroblast activation protein-a-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma. BMC Gastroenterol 15:109 (2015). IHC . PubMed: 26330349
  • Katare R  et al. Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. Arterioscler Thromb Vasc Biol 34:408-18 (2014). PubMed: 24202301
  • Benesch MG  et al. Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice. FASEB J 28:2655-66 (2014). PubMed: 24599971
  • Huang R  et al. CD117 expression in fibroblasts-like stromal cells indicates unfavorable clinical outcomes in ovarian carcinoma patients. PLoS One 9:e112209 (2014). IHC-P ; Human . PubMed: 25380303
  • Guan J  et al. Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells. Cancer Lett 345:132-9 (2014). PubMed: 24334138
  • Amini-Nik S  et al. ß-Catenin-regulated myeloid cell adhesion and migration determine wound healing. J Clin Invest 124:2599-610 (2014). IHC-P ; Mouse . PubMed: 24837430
  • Peng Q  et al. Biological characteristics and genetic heterogeneity between carcinoma-associated fibroblasts and their paired normal fibroblasts in human breast cancer. PLoS One 8:e60321 (2013). ICC/IF ; Human . PubMed: 23577100
  • Willimsky G  et al. Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance. J Clin Invest 123:1032-43 (2013). IHC-P ; Mouse . PubMed: 23454765
  • Yanez CO  et al. Deep vascular imaging in wounds by two-photon fluorescence microscopy. PLoS One 8:e67559 (2013). IHC-P . PubMed: 23844028
  • Shintani Y  et al. Pulmonary fibroblasts induce epithelial mesenchymal transition and some characteristics of stem cells in non-small cell lung cancer. Ann Thorac Surg 96:425-33 (2013). PubMed: 23773734
  • Ng YZ  et al. Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa. Cancer Res 72:3522-34 (2012). Human . PubMed: 22564523
  • Hellevik T  et al. Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced. Radiat Oncol 7:59 (2012). ICC/IF ; Human . PubMed: 22500976
  • Juillerat-Jeanneret L  et al. Peptides from Lactobacillus hydrolysates of bovine milk caseins inhibit prolyl-peptidases of human colon cells. J Agric Food Chem 59:370-7 (2011). IHC-P ; Human . PubMed: 21126072
  • Matsui Y  et al. Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction. Circ Res 108:1328-39 (2011). IHC-P ; Mouse . PubMed: 21493899
  • Saigusa S  et al. Cancer-associated fibroblasts correlate with poor prognosis in rectal cancer after chemoradiotherapy. Int J Oncol 38:655-63 (2011). PubMed: 21240461
  • Pinto MP  et al. An immunohistochemical method to study breast cancer cell subpopulations and their growth regulation by hormones in three-dimensional cultures. Front Endocrinol (Lausanne) 2:15 (2011). PubMed: 22649363
  • Abu El-Asrar AM  et al. Expression of myofibroblast activation molecules in proliferative vitreoretinopathy epiretinal membranes. Acta Ophthalmol 89:e115-21 (2011). PubMed: 20528783
  • Anees M  et al. Recurrence-free survival in prostate cancer is related to increased stromal TRAIL expression. Cancer 117:1172-82 (2011). PubMed: 21381010
  • Wang J  et al. Characterization of phosphoglycerate kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer progression. Cancer Res 70:471-80 (2010). ICC, IHC ; Human . PubMed: 20068185
  • Pinto MP  et al. Vascular endothelial growth factor secreted by activated stroma enhances angiogenesis and hormone-independent growth of estrogen receptor-positive breast cancer. Cancer Res 70:2655-64 (2010). IHC-P ; Mouse . PubMed: 20332242
  • Tarnowski M  et al. Macrophage Migration Inhibitory Factor Is Secreted by Rhabdomyosarcoma Cells, Modulates Tumor Metastasis by Binding to CXCR4 and CXCR7 Receptors and Inhibits Recruitment of Cancer-Associated Fibroblasts. Mol Cancer Res 8:1328-43 (2010). IHC-Fr ; Mouse . PubMed: 20861157
  • Chen H  et al. TGF-beta-induced fibroblast activation protein expression, fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM. Exp Mol Pathol 87:189-94 (2009). WB, ICC/IF ; Mouse . PubMed: 19747910
  • Santos AM  et al. Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest 119:3613-25 (2009). IHC-P ; Mouse . PubMed: 19920354
  • Goscinski MA  et al. FAP-alpha and uPA show different expression patterns in premalignant and malignant esophageal lesions. Ultrastruct Pathol 32:89-96 (2008). WB, IHC-P ; Human . PubMed: 18570153

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