Product nameFibroblast activation protein, alpha peptide
See all Fibroblast activation protein, alpha proteins and peptides
Immunizing Peptide (Blocking)
Our Abpromise guarantee covers the use of ab150744 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 10% DMSO, 0.1% BSA
Note: 50mM Tris, 5mM EDTA
- 170 kDa melanoma membrane bound gelatinase
- 170 kDa melanoma membrane-bound gelatinase
FunctionIn association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.
Tissue specificityFibroblast specific.
Sequence similaritiesBelongs to the peptidase S9B family.
The N-terminus may be blocked.
Cellular localizationCell membrane. Cell projection > lamellipodium membrane. Cell projection > invadopodium membrane. Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma.
- Information by UniProt
ab150744 has not yet been referenced specifically in any publications.