• Product name

    Anti-Fibulin 1 antibody [CL0337]
    See all Fibulin 1 primary antibodies
  • Description

    Mouse monoclonal [CL0337] to Fibulin 1
  • Host species

  • Tested applications

    Suitable for: IHC, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant fragment (proprietary-tag) corresponding to Human Fibulin 1 aa 266-402.


    Database link: P23142

  • Positive control

    • Human plasma; human testis, uterus, prostate, placenta and breast cancer tissues.



Our Abpromise guarantee covers the use of ab211536 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC 1/50 - 1/200.
WB 1/500 - 1/1000. Predicted molecular weight: 77 kDa.


  • Function

    Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
  • Tissue specificity

    Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.
  • Involvement in disease

    Note=A chromosomal aberration involving FBLN1 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with C12orf2. Fibroblasts derived from a patient with synpolydactyly displayed alterations in the level of isoform D splice variant incorporated into the ECM and secreted into the conditioned culture medium. By contrast, the expression of isoform C was not perturbed in the patients fibroblasts. Furthermore, no aberrant polypeptides were detected in extracts of cultured patients fibroblasts. The translocation t(12;22) may result in haploinsufficiency of the isoform D splice variant, which could lead to the observed limb malformation.
    Note=Elevated expression and altered processing of FBLN1 protein is associated with human breast cancer.
  • Sequence similarities

    Belongs to the fibulin family.
    Contains 3 anaphylatoxin-like domains.
    Contains 9 EGF-like domains.
  • Developmental stage

    Widely expressed during embryonic development. Prominent in the matrix of the leptomeningeal anlage, in basement membranes of the neuroepithelium and the perineurium of peripheral nerves. In embryos of gestational week (gw) 4, staining was observed in the early mesenchymal bone anlagen. In gw 6.5 and 8, all perichondrial structures showed expression but the chondrocytes themselves showed no staining. In gw 10, expression is prominent in the interterritorial matrix surrounding the hypertrophic chondrocytes.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • Basement membrane protein 90 antibody
    • BM 90 antibody
    • FBLN antibody
    • Fbln1 antibody
    • FBLN1_HUMAN antibody
    • FIBL 1 antibody
    • FIBL-1 antibody
    • FIBL1 antibody
    • Fibulin 1 antibody
    • Fibulin-1 antibody
    see all


  • Immunohistochemical analysis of Human breast cancer tissue labeling Fibulin 1 with ab211536 at 1/50 dilution.

  • Immunohistochemical analysis of Human placenta tissue labeling Fibulin 1 with ab211536 at 1/50 dilution.

  • Immunohistochemical analysis of Human prostate tissue labeling Fibulin 1 with ab211536 at 1/50 dilution.

  • Immunohistochemical analysis of Human uterus tissue labeling Fibulin 1 with ab211536 at 1/50 dilution.

  • Immunohistochemical analysis of Human testis tissue labeling Fibulin 1 with ab211536 at 1/50 dilution.

  • Anti-Fibulin 1 antibody [CL0337] (ab211536) at 1/500 dilution + Human plasma

    Predicted band size: 77 kDa


This product has been referenced in:

  • Bartoschek M  et al. Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing. Nat Commun 9:5150 (2018). Read more (PubMed: 30514914) »
See 1 Publication for this product

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