• Product name

    Anti-Filamin C antibody [EPR14498(B)]
    See all Filamin C primary antibodies
  • Description

    Rabbit monoclonal [EPR14498(B)] to Filamin C
  • Host species

  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Filamin C aa 2700 to the C-terminus. The exact sequence is proprietary.
    Database link: Q14315

  • Positive control

    • Human skeletal muscle and fetal heart lysates; Human muscle tissue.
  • General notes



    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab180941 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Detects a band of approximately 291 kDa (predicted molecular weight: 291 kDa).
IHC-P 1/250. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.


  • Relevance

    FLNC is a muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z-disks in muscle cells. Defects in FLNC are the cause of autosomal dominant filaminopathy. Myofibrillar myopathy (MFM) is a neuromuscular disorder, usually with an adult onset, characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations. Autosomal dominant filaminopathy is a form of MFM characterized by morphological features of MFM and clinical features of a limb-girdle myopathy. A heterozygous nonsense mutation which segregates with the disease, has been identified in the FLNC gene.
  • Cellular localization

  • Database links

  • Alternative names

    • ABPL antibody
    • Actin binding like protein antibody
    • FIlamin 2 antibody
    • Filamin C antibody
    • FLN2 antibody
    • Gamma filamin antibody
    see all


  • All lanes : Anti-Filamin C antibody [EPR14498(B)] (ab180941) at 1/50000 dilution

    Lane 1 : Human skeletal muscle lysate
    Lane 2 : Human fetal heart lysate

    Lysates/proteins at 20 µg per lane.

    All lanes : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

    Predicted band size: 291 kDa
    Observed band size: 291 kDa

  • Immunohistochemical analysis of paraffin-embedded Human muscle tissue labeling Filamin C with ab180941 at 1/250 dilution, followed by prediluted HRP Polymer for Rabbit IgG. Counter stained with Hematoxylin.

    Perform heat mediated antigen retrieval with EDTA buffer pH 9 before commencing with IHC staining protocol.


This product has been referenced in:

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