Overview

  • Product name

    Finasteride, Type II 5alpha-reductase inhibitor
  • Description

    Selective type II 5α-reductase inhibitor
  • Biological description

    Type II 5α-reductase inhibitor (IC50 values are 11.3 and 313 nM at type II and type I respectively). Reduces prostate gland size. Suppresses conversion of testosterone to dihydrotestosterone. Active in vivo and orally active.
  • Purity

    > 99%
  • CAS Number

    98319-26-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(1,1-Dimethylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-
    4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
  • Molecular weight

    372.55
  • Molecular formula

    C23H36N2O2
  • PubChem identifier

    57363
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C)NC(=O)[C@H]4CC[C@@H]3[C@]4(C)CC[C@H]1[C@H]3CC[C@H]2NC(=O)C=C[C@]12C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mukai Y  et al. Studies on neurosteroids XXV. Influence of a 5alpha-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism. Biol Pharm Bull 31:1646-50 (2008). Read more (PubMed: 18758053) »
  • Gao W  et al. Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology 145:5420-8 (2004). Read more (PubMed: 15308613) »
  • Zaccheo T  et al. Combined treatment with the 5 alpha-reductase inhibitor PNU 157706 and the antiandrogen flutamide on the Dunning R3327 prostatic carcinoma in rats. Endocr Relat Cancer 6:429-35 (1999). Read more (PubMed: 10516856) »

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