Key features and details
- FITC Goat polyclonal to C1q
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
Product nameFITC Anti-C1q antibody
See all C1q primary antibodies
DescriptionFITC Goat polyclonal to C1q
ConjugationFITC. Ex: 493nm, Em: 528nm
Species reactivityReacts with: Human
Full length native protein (purified) corresponding to Human C1q.
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FormLyophilized:Reconstitute in 1 ml sterile distilled water
Storage instructionsShipped at 4°C. Store at +4°C. Store In the Dark.
Storage bufferpH: 7.20
Constituent: 100% PBS
Concentration information loading...
Purification notesThe anti-Serum does not cross-react with any other component of Human plasma.
FunctionC1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Involvement in diseaseDefects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
Sequence similaritiesContains 1 C1q domain.
Contains 1 collagen-like domain.
modificationsO-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
- Information by UniProt
- C1qa antibody
- C1QA_HUMAN antibody
- C1QB antibody
ab182940 has not yet been referenced specifically in any publications.