FITC Anti-C4c+C4b antibody (ab4216)
Key features and details
- FITC Rabbit polyclonal to C4c+C4b
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
Overview
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Product name
FITC Anti-C4c+C4b antibody -
Description
FITC Rabbit polyclonal to C4c+C4b -
Host species
Rabbit -
Conjugation
FITC. Ex: 493nm, Em: 528nm -
Specificity
This antibody reacts with human C4, C4b and C4c but does not react with the C4d epitope. -
Species reactivity
Reacts with: Human -
Immunogen
C4c complement isolated from complement activated human serum.
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General notes
Fluorescein isothiocyanate (FITC) isomer 1.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
Purity
IgG fraction -
Purification notes
Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Isotype control
Target
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Relevance
C4 plays a central role in the activation of the classical pathway of the complement system. Human complement component C4 is polymorphic at two loci, C4A and C4B. The C4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch) blood group antigens. C4 (either allele A or B) protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase. -
Cellular localization
Secreted -
Database links
- Entrez Gene: 720 Human
- Entrez Gene: 721 Human
- SwissProt: P0C0L4 Human
- SwissProt: P0C0L5 Human
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Alternative names
- Acidic complement C4 antibody
- Basic complement C4 antibody
- CH antibody
see all
Datasheets and documents
References (1)
ab4216 has been referenced in 1 publication.
- Ispasanie E et al. Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations. Virulence 9:1138-1149 (2018). PubMed: 30067453
