FITC Anti-CD105 antibody [MJ718] (ab184667)
![Flow Cytometry - FITC Anti-CD105 antibody [MJ718] (ab184667)](https://www.abcam.com/ps/products/184/ab184667/Images/ab184667-215681-anti-cd105-antibody-mj718-fitc-flow-cytometry.jpg "Flow Cytometry - FITC Anti-CD105 antibody [MJ718] (ab184667)")
Key features and details
- FITC Rat monoclonal [MJ718] to CD105
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG2a
Overview
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Product name
FITC Anti-CD105 antibody [MJ718]
See all CD105 primary antibodies -
Description
FITC Rat monoclonal [MJ718] to CD105 -
Host species
Rat -
Conjugation
FITC. Ex: 493nm, Em: 528nm -
Tested applications
Suitable for: Flow Cytmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Tissue, cells or virus corresponding to Mouse CD105. ab184667 was produced by immunizing rats with inflamed mouse skin (murine stromal cell line). NCBI Accession No. NP_031958.2
Database link: Q63961 -
Positive control
- Mouse endothelial cells.
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General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. Store In the Dark. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituents: 1% BSA, 98% PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
MJ718 -
Isotype
IgG2a -
Research areas
Associated products
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab184667 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Flow Cyt | Use a concentration of 5 µg/ml. in a volume of 100 µl
ab18446 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
|
Target
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Function
Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. -
Tissue specificity
Endoglin is restricted to endothelial cells in all tissues except bone marrow. -
Involvement in disease
Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 13805 Mouse
- SwissProt: Q63961 Mouse
- Unigene: 225297 Mouse
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Alternative names
- AI528660 antibody
- AI662476 antibody
- CD 105 antibody
see all
Images
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Flow Cytometry - FITC Anti-CD105 antibody [MJ718] (ab184667)
Flow cytometry analysis of mouse endothelial cells labeling CD105. Upper panel: no primary antibody; Middle panel: solely conjugated secondary antibody; Lower panel: ab184667 at 5 µg/ml.
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![Flow Cytometry - FITC Anti-CD105 antibody [MJ718] (ab184667)](https://www.abcam.com/ps/products/184/ab184667/Images/ab184667-215680-anti-cd105-antibody-mj718-fitc-flow-cytometry.jpg)
Flow Cytometry - FITC Anti-CD105 antibody [MJ718] (ab184667)Flow cytometry analysis of mouse endothelial cells labeling CD105, using ab184667 at 5 µg/ml (red-filled histogram).
Datasheets and documents
References (3)
ab184667 has been referenced in 3 publications.
- Zhao SJ et al. Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3ß/ß-catenin pathway. Theranostics 10:17-35 (2020). PubMed: 31903103
- Shojafar E et al. Adipose-derived mesenchymal stromal cell transplantation at the graft site improves the structure and function of autografted mice ovaries: a stereological and biochemical analysis. Cytotherapy 20:1324-1336 (2018). PubMed: 30360962
- Wang B et al. MicroRNA expression in bone marrow mesenchymal stem cells from mice with steroid-induced osteonecrosis of the femoral head. Mol Med Rep 12:7447-54 (2015). PubMed: 26459755
