Key features and details
- FITC Armenian hamster monoclonal [H146-968] to CD3 zeta
- Reacts with: Mouse, Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
Product nameFITC Anti-CD3 zeta antibody [H146-968]
See all CD3 zeta primary antibodies
DescriptionFITC Armenian hamster monoclonal [H146-968] to CD3 zeta
Host speciesArmenian hamster
ConjugationFITC. Ex: 493nm, Em: 528nm
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat, Sheep, Rabbit, Cow, Pig, Xenopus laevis
Purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.
This product was changed from ascites to tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 8.00
Preservative: 0.097% Sodium azide
Constituent: Tris buffered saline
Concentration information loading...
Purification notesPurified from TCS
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionProbable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Involvement in diseaseDefects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.
Sequence similaritiesBelongs to the CD3Z/FCER1G family.
Contains 3 ITAM domains.
DomainThe ITAM domains mediate interaction with SHB.
modificationsPhosphorylated on Tyr residues after T-cell receptor triggering.
- Information by UniProt
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ab91493 has been referenced in 1 publication.
- Pieren DKJ et al. Response kinetics reveal novel features of ageing in murine T cells. Sci Rep 9:5587 (2019). PubMed: 30944406