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  1. Link

    fitc-cd79b-antibody-at107-2-ab33296.pdf

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Immunology Adaptive Immunity B Cells CD
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FITC Anti-CD79b antibody [AT107-2] (ab33296)

  • Datasheet
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Flow Cytometry - FITC Anti-CD79b antibody [AT107-2] (ab33296)

    Key features and details

    • FITC Rat monoclonal [AT107-2] to CD79b
    • Suitable for: Flow Cyt
    • Reacts with: Mouse, Rat, Dog, Human, Pig
    • Conjugation: FITC. Ex: 493nm, Em: 528nm
    • Isotype: IgG1

    Overview

    • Product name

      FITC Anti-CD79b antibody [AT107-2]
      See all CD79b primary antibodies
    • Description

      FITC Rat monoclonal [AT107-2] to CD79b
    • Host species

      Rat
    • Conjugation

      FITC. Ex: 493nm, Em: 528nm
    • Specificity

      Recognises an intracellular region of human CD79b We have data to indicate that this antibody may not cross react with Chicken. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
    • Tested applications

      Suitable for: Flow Cytmore details
    • Species reactivity

      Reacts with: Mouse, Rat, Dog, Human, Pig
    • Immunogen

      Synthetic peptide corresponding to an intracellular region of human CD79b.

    • Positive control

      • Rat peripheral blood lymphocytes.
    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C.
    • Storage buffer

      pH: 7.40
      Preservative: 0.09% Sodium azide
      Constituents: PBS, 1% BSA
    • Concentration information loading...
    • Purity

      Protein G purified
    • Clonality

      Monoclonal
    • Clone number

      AT107-2
    • Myeloma

      NS1
    • Isotype

      IgG1
    • Research areas

      • Immunology
      • Adaptive Immunity
      • B Cells
      • CD

    Associated products

    • Isotype control

      • FITC Rat IgG1, kappa [RTK2071] - isotype control (ab18404)

    Applications

    Our Abpromise guarantee covers the use of ab33296 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Flow Cyt
  • Application notes
    Flow Cyt: Use 10µl for 106 cells in 100µl.
    Note: Membrane permeabilisation is required for this application.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
    • Tissue specificity

      B-cells.
    • Involvement in disease

      Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
    • Sequence similarities

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Contains 1 ITAM domain.
    • Post-translational
      modifications

      Phosphorylated on tyrosine upon B-cell activation.
    • Cellular localization

      Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
    • Target information above from: UniProt accession P40259 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 974 Human
      • Entrez Gene: 15985 Mouse
      • Entrez Gene: 171055 Rat
      • Omim: 147245 Human
      • SwissProt: P40259 Human
      • SwissProt: P15530 Mouse
      • Unigene: 89575 Human
      • Unigene: 2987 Mouse
      • Unigene: 62607 Rat
      see all
    • Alternative names

      • AGM6 antibody
      • B cell antigen receptor complex associated protein beta chain antibody
      • B cell specific glycoprotein B29 antibody
      • B-cell antigen receptor complex-associated protein beta chain antibody
      • B-cell-specific glycoprotein B29 antibody
      • B29 antibody
      • B29/Ig-beta/CD79b antibody
      • CD 79b antibody
      • CD79b antibody
      • CD79b antigen (immunoglobulin associated beta) antibody
      • CD79b antigen antibody
      • CD79b molecule antibody
      • CD79b molecule immunoglobulin associated beta antibody
      • CD79b protein antibody
      • CD79B_HUMAN antibody
      • Ig beta antibody
      • Ig-beta antibody
      • IGB antibody
      • Igbeta antibody
      • Immunoglobulin associated B29 antibody
      • Immunoglobulin associated B29 protein antibody
      • Immunoglobulin associated beta antibody
      • Immunoglobulin associated protein antibody
      • Immunoglobulin-associated B29 protein antibody
      • MGC108607 antibody
      see all

    Images

    • Flow Cytometry - FITC Anti-CD79b antibody [AT107-2] (ab33296)
      Flow Cytometry - FITC Anti-CD79b antibody [AT107-2] (ab33296)
      Staining of rat peripheral blood lymphocytes with ab33296 after permeabilisation.

    Protocols

    • Flow cytometry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (1)

    Publishing research using ab33296? Please let us know so that we can cite the reference in this datasheet.

    ab33296 has been referenced in 1 publication.

    • Sun Z  et al. Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis. Int J Mol Med 33:1097-109 (2014). Flow Cyt ; Rat . PubMed: 24573542

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