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    fitc-cd84-antibody-cd84121-ab33217.pdf

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Immunology Adaptive Immunity B Cells CD
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FITC Anti-CD84 antibody [CD84.1.21] (ab33217)

  • Datasheet
  • SDS
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Key features and details

  • FITC Mouse monoclonal [CD84.1.21] to CD84
  • Reacts with: Human
  • Conjugation: FITC. Ex: 493nm, Em: 528nm
  • Isotype: IgG1

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Overview

  • Product name

    FITC Anti-CD84 antibody [CD84.1.21]
    See all CD84 primary antibodies
  • Description

    FITC Mouse monoclonal [CD84.1.21] to CD84
  • Host species

    Mouse
  • Conjugation

    FITC. Ex: 493nm, Em: 528nm
  • Specificity

    Recognizes CD84 cell surface antigen, a highly glycosylated cell surface antigen of 64-82kD.
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Mouse pre-B cell line 300.19 transfected with Human CD84 cDNA.

  • Positive control

    • Whole blood
  • General notes

    Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC).

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituents: PBS, 1% BSA
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    CD84.1.21
  • Myeloma

    NS1
  • Isotype

    IgG1
  • Research areas

    • Immunology
    • Adaptive Immunity
    • B Cells
    • CD
    • Stem Cells
    • Hematopoietic Progenitors
    • Surface Molecules

Associated products

  • Alternative Versions

    • PE Anti-CD84 antibody [CD84.1.21] (ab33218)
  • Isotype control

    • FITC Mouse IgG1 [B11/6] - Isotype Control (ab91356)
  • Recombinant Protein

    • Recombinant human CD84 protein (ab182681)

Applications

  • Application notes
    Flow Cyt: Use 10µl for 106 cells or 100µl whole blood.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.
    • Tissue specificity

      Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells.
    • Sequence similarities

      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    • Developmental stage

      Expression is slightly increased in naive B-cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division.
    • Domain

      ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A.
    • Post-translational
      modifications

      Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic domain Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation.
      N-glycosylated.
    • Cellular localization

      Cell membrane.
    • Target information above from: UniProt accession Q9UIB8 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 8832 Human
      • Omim: 604513 Human
      • SwissProt: Q9UIB8 Human
      • Unigene: 398093 Human
      • Alternative names

        • CD_antigen=CD84 antibody
        • CD84 antibody
        • CD84 antigen antibody
        • CD84 molecule antibody
        • CDw84 antibody
        • Cell surface antigen MAX.3 antibody
        • hCD84 antibody
        • Hly9 beta antibody
        • Hly9-beta antibody
        • Leucocyte differentiation antigen CD84 antibody
        • Leukocyte Antigen antibody
        • Leukocyte antigen CD84 antibody
        • Leukocyte differentiation antigen antibody
        • Leukocyte differentiation antigen CD84 antibody
        • LY9B antibody
        • mCD84 antibody
        • Signaling lymphocytic activation molecule 5 antibody
        • SLAF5_HUMAN antibody
        • SLAM family member 5 antibody
        • SLAMF5 antibody
        see all

      Protocols

      • Flow cytometry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab33217? Please let us know so that we can cite the reference in this datasheet.

      ab33217 has not yet been referenced specifically in any publications.

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