FITC Anti-CD84 antibody [CD84.1.21] (ab33217)

Submit a review Submit a question

Key features and details

  • FITC Mouse monoclonal [CD84.1.21] to CD84
  • Reacts with: Human
  • Conjugation: FITC. Ex: 493nm, Em: 528nm
  • Isotype: IgG1

Overview

  • Product name

    FITC Anti-CD84 antibody [CD84.1.21]
    See all CD84 primary antibodies

  • Description

    FITC Mouse monoclonal [CD84.1.21] to CD84

  • Host species

    Mouse

  • Conjugation

    FITC. Ex: 493nm, Em: 528nm

  • Specificity

    Recognizes CD84 cell surface antigen, a highly glycosylated cell surface antigen of 64-82kD.

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Mouse pre-B cell line 300.19 transfected with Human CD84 cDNA.

  • Positive control

    • Whole blood

  • General notes

    Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC).

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid

  • Storage instructions

    Shipped at 4°C. Store at +4°C.

  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituents: PBS, 1% BSA
  • Concentration information loading...

  • Purity

    Protein G purified

  • Purification notes

    Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

  • Clonality

    Monoclonal

  • Clone number

    CD84.1.21

  • Myeloma

    NS1

  • Isotype

    IgG1

  • Research areas

Applications

  • Application notes
    Flow Cyt: Use 10µl for 106 cells or 100µl whole blood.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • Function

      Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.

    • Tissue specificity

      Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells.

    • Sequence similarities

      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

    • Developmental stage

      Expression is slightly increased in naive B-cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division.

    • Domain

      ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A.

    • Post-translational
      modifications

      Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic domain Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation.
      N-glycosylated.

    • Cellular localization

      Cell membrane.
    • Information by UniProt

    • Database links

      • Alternative names

        • CD_antigen=CD84 antibody
        • CD84 antibody
        • CD84 antigen antibody
        • CD84 molecule antibody
        • CDw84 antibody
        • Cell surface antigen MAX.3 antibody
        • hCD84 antibody
        • Hly9 beta antibody
        • Hly9-beta antibody
        • Leucocyte differentiation antigen CD84 antibody
        • Leukocyte Antigen antibody
        • Leukocyte antigen CD84 antibody
        • Leukocyte differentiation antigen antibody
        • Leukocyte differentiation antigen CD84 antibody
        • LY9B antibody
        • mCD84 antibody
        • Signaling lymphocytic activation molecule 5 antibody
        • SLAF5_HUMAN antibody
        • SLAM family member 5 antibody
        • SLAMF5 antibody
        see all

      References (0)

      Publishing research using ab33217? Please let us know so that we can cite the reference in this datasheet.

      ab33217 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

      Show All Reviews Q&A
      Submit a review Submit a question

      There are currently no Customer reviews or Questions for ab33217.
      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com