Key features and details
- FITC Goat polyclonal to Chlamydia trachomatis MOMP
- Suitable for: IHC-P, ICC/IF
- Reacts with: Chlamydia trachomatis
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
Product nameFITC Anti-Chlamydia trachomatis MOMP antibody
See all Chlamydia trachomatis MOMP primary antibodies
DescriptionFITC Goat polyclonal to Chlamydia trachomatis MOMP
ConjugationFITC. Ex: 493nm, Em: 528nm
Specificityab30951 recognises Major Outer Membrane Protein of Chlamydia trachomatis.
Tested applicationsSuitable for: IHC-P, ICC/IFmore details
Species reactivityReacts with: Chlamydia trachomatis
Full length protein: Chlamydia trachomatis, Major Outer Membrane Protein
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.20
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA
Concentration information loading...
Purification notesab30951 was chromatographically purified.
Our Abpromise guarantee covers the use of ab30951 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use at an assay dependent concentration.|
|ICC/IF||1/20 - 1/100.|
RelevanceChlamydia is caused by the bacterium Chlamydia trachomatis. The intracytoplasmic inclusions caused by the bacterium are draped around the infected cell's nucleus. Chlamydia trachomatis is an intracellular organism that has a genome size of approximately 500-1000 kilobases and contains both RNA and DNA. The organism is also extremely temperature sensitive and must be refrigerated at 4°C as soon as a sample is obtained. Colonization of Chlamydia begins with attachment to sialic acid receptors on the eye, throat or genitalia. It persists at body sites that are inaccessible to phagocytes, T cells, and B cells. It also exists as 15 different serotypes. These serotypes cause four major diseases in humans: endemic trachoma (caused by serotypes A and C), sexually transmitted disease and inclusion conjunctivitis (caused by serotypes D and K), and lymphogranuloma venereum (caused by serotypes L1, L2, and L3). Studies reveal that Chlamydia, because of its cell wall, is able to inhibit phagolysosome fusion in phagocytes. The cell wall is proposed to be Gram negative in that it contains an outer lipopolysaccharide membrane, but it lacks peptidoglycan in its cell wall. This lack of peptidoglycan is shown by the inability to detect muramic acid and antibodies directed against it. It may, however, contain a carboxylated sugar other than muramic acid. The proposed structure consists of a major outer membrane protein cross linked with disulfide bonds. It also contains cysteine rich proteins (CRP) that may be the functional equivalent to peptidoglycan. This unique structure allows for intracellular division and extracellular survival (Hatch 1996). Chlamydia usually infects the cervix and fallopian tubes of women and the urethra of men. Chlamydial infections are believed to be one of the most common of all STDs. It is generally thought that in a population of 15 million, there are up to 300,000 cases of chlamydia each year. Thus, there are many undiagnosed cases of chlamydia in the community. It has been estimated that the true prevalence of chlamydia in the sexually active population may be in the order of 5% to 10%. Chlamydia is one of the leading causes of blindness in underdeveloped countries.
Cellular localizationOuter membrane; multi pass membrane protein.
- Entrez Gene: 3688076 Chlamydia trachomatis
- Entrez Gene: 884473 Chlamydia trachomatis
- SwissProt: P06597 Chlamydia trachomatis
- SwissProt: P08780 Chlamydia trachomatis
- SwissProt: P13467 Chlamydia trachomatis
- SwissProt: P16155 Chlamydia trachomatis
- SwissProt: P17451 Chlamydia trachomatis
- SwissProt: P19542 Chlamydia trachomatis
- Major Outer Membrane Protein antibody
- MOMP antibody
- omp1 antibody
ab30951 has been referenced in 1 publication.
- Derrick T et al. Inverse relationship between microRNA-155 and -184 expression with increasing conjunctival inflammation during ocular Chlamydia trachomatis infection. BMC Infect Dis 16:60 (2016). PubMed: 26842862