FITC Anti-Cyclin B1 antibody [V152] (ab187806)

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Key features and details

  • FITC Mouse monoclonal [V152] to Cyclin B1
  • Reacts with: Human
  • Conjugation: FITC. Ex: 493nm, Em: 528nm
  • Isotype: IgG1

Overview

  • Product name

    FITC Anti-Cyclin B1 antibody [V152]
    See all Cyclin B1 primary antibodies

  • Description

    FITC Mouse monoclonal [V152] to Cyclin B1

  • Host species

    Mouse

  • Conjugation

    FITC. Ex: 493nm, Em: 528nm

  • Specificity

    ab187806 recognises G2/mitotic-specific cyclin-B1. Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin B1 is a marker of cell proliferation and a key component of the cell cycle progression machinery. ab187806 recognises an epitope within the C-terminal region of cyclin B1.

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Recombinant full length protein (His-tag) corresponding to Hamster Cyclin B1. Expressed in bacteria, harvested from inclusion bodies
    Database link: P14635

  • Epitope

    ab187806 recognises an epitope within the C-terminal region of cyclin B1.

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

Target

  • Function

    Essential for the control of the cell cycle at the G2/M (mitosis) transition.

  • Sequence similarities

    Belongs to the cyclin family. Cyclin AB subfamily.

  • Developmental stage

    Accumulates steadily during G2 and is abruptly destroyed at mitosis.

  • Post-translational
    modifications

    Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.

  • Cellular localization

    Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome.
  • Information by UniProt

  • Database links

    • Alternative names

      • CCNB 1 antibody
      • CCNB antibody
      • ccnb1 antibody
      • CCNB1_HUMAN antibody
      • Cyclin B1 antibody
      • G2 mitotic specific cyclin B1 antibody
      • G2/mitotic-specific cyclin-B1 antibody
      see all

    References (0)

    Publishing research using ab187806? Please let us know so that we can cite the reference in this datasheet.

    ab187806 has not yet been referenced specifically in any publications.

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