Key features and details
- FITC Rat monoclonal [2A11] to Dectin-1
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG2b
Product nameFITC Anti-Dectin-1 antibody [2A11]
See all Dectin-1 primary antibodies
DescriptionFITC Rat monoclonal [2A11] to Dectin-1
ConjugationFITC. Ex: 493nm, Em: 528nm
Tested applicationsSuitable for: Flow Cytmore details
Species reactivityReacts with: Mouse
Recombinant full length protein corresponding to Dectin-1.
This antibody inhibits the binding of zymosan to macrophages via the beta Glucan Receptor.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA
Concentration information loading...
PurityProtein G purified
Primary antibody notesThis antibody inhibits the binding of zymosan to macrophages via the beta Glucan Receptor.
Our Abpromise guarantee covers the use of ab21646 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Flow Cyt||Use 10µl for 106 cells.
Use 10µl for 106 cells in 100µl.
ab136125 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
FunctionLectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.
Tissue specificityHighly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
Involvement in diseaseDefects in CLEC7A may be a cause of familial candidiasis type 4 (CANDF4) [MIM:613108]. It is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Sequence similaritiesContains 1 C-type lectin domain.
modificationsPhosphorylated on tyrosine residues in response to glucan binding.
Cellular localizationCytoplasm and Cell membrane.
- Information by UniProt
- Beta GR antibody
- Beta-glucan receptor antibody
- BGR antibody
ab21646 has been referenced in 1 publication.
- Daley D et al. Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance. Nat Med 23:556-567 (2017). IHC-Fr, Flow Cyt ; Mouse . PubMed: 28394331