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    fitc-dr5-antibody-dr5-01-1-ab53319.pdf

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Cell Biology Apoptosis Receptors Death Receptors
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FITC Anti-DR5 antibody [DR5-01-1] (ab53319)

  • Datasheet
  • SDS
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Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (ab53319)

    Key features and details

    • FITC Mouse monoclonal [DR5-01-1] to DR5
    • Suitable for: Flow Cyt
    • Reacts with: Human
    • Conjugation: FITC. Ex: 493nm, Em: 528nm
    • Isotype: IgG1

    Conjugates logo Related conjugates and formulations

    APC PE Unconjugated

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    Overview

    • Product name

      FITC Anti-DR5 antibody [DR5-01-1]
      See all DR5 primary antibodies
    • Description

      FITC Mouse monoclonal [DR5-01-1] to DR5
    • Host species

      Mouse
    • Conjugation

      FITC. Ex: 493nm, Em: 528nm
    • Tested applications

      Suitable for: Flow Cytmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.

    • General notes

      The reagent is free of unconjugated FITC.

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C.
    • Storage buffer

      pH: 7.4
      Preservative: 0.097% Sodium azide
      Constituents: 0.2% BSA, PBS
    • Concentration information loading...
    • Purity

      Protein G purified
    • Clonality

      Monoclonal
    • Clone number

      DR5-01-1
    • Isotype

      IgG1
    • Research areas

      • Cell Biology
      • Apoptosis
      • Receptors
      • Death Receptors
      • Signal Transduction
      • Growth Factors/Hormones
      • TNF
      • Cancer
      • Growth factors
      • TNF
      • Cardiovascular
      • Angiogenesis
      • Endothelial Cell Markers

    Associated products

    • Alternative Versions

      • Anti-DR5 antibody [DR5-01-1] (ab166650)
      • PE Anti-DR5 antibody [DR5-01-1] (ab55863)
    • Isotype control

      • FITC Mouse IgG1 [B11/6] - Isotype Control (ab91356)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab53319 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Flow Cyt
    Use a concentration of 1 - 5 µg/ml.
    Notes
    Flow Cyt
    Use a concentration of 1 - 5 µg/ml.

    Target

    • Function

      Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
    • Tissue specificity

      Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
    • Involvement in disease

      Squamous cell carcinoma of the head and neck
    • Sequence similarities

      Contains 1 death domain.
      Contains 3 TNFR-Cys repeats.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession O14763 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 8795 Human
      • Omim: 603612 Human
      • SwissProt: O14763 Human
      • Unigene: 521456 Human
      • Unigene: 661668 Human
      • Alternative names

        • Fas like protein antibody
        • Apoptosis inducing protein TRICK2A/2B antibody
        • Apoptosis inducing receptor TRAIL R2 antibody
        • CD262 antibody
        • CD262 antigen antibody
        • Cytotoxic TRAIL receptor 2 antibody
        • Death domain containing receptor for TRAIL/Apo 2L antibody
        • Death receptor 5 antibody
        • DR5 antibody
        • KILLER antibody
        • KILLER/DR5 antibody
        • OTTHUMP00000123492 antibody
        • OTTHUMP00000123493 antibody
        • p53 regulated DNA damage inducible cell death receptor(killer) antibody
        • TNF related apoptosis inducing ligand receptor 2 antibody
        • TNF-related apoptosis-inducing ligand receptor 2 antibody
        • TNFRSF10B antibody
        • TR10B_HUMAN antibody
        • TRAIL R2 antibody
        • TRAIL receptor 2 antibody
        • TRAIL-R2 antibody
        • TRAILR2 antibody
        • TRICK2 antibody
        • TRICK2A antibody
        • TRICK2B antibody
        • TRICKB antibody
        • Tumor necrosis factor receptor like protein ZTNFR9 antibody
        • Tumor necrosis factor receptor superfamily member 10B antibody
        • Tumor necrosis factor receptor superfamily, member 10b antibody
        • ZTNFR9 antibody
        see all

      Images

      • Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (ab53319)
        Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (ab53319)

        Flow cytometry analysis (surface staining) of CD262 on CD262-transfectants using ab53319 at 5 μg/ml. 

      Protocols

      • Flow cytometry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (2)

      Publishing research using ab53319? Please let us know so that we can cite the reference in this datasheet.

      ab53319 has been referenced in 2 publications.

      • Strekalova E  et al. Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction. Methods Mol Biol 1866:61-73 (2019). PubMed: 30725408
      • Pan L  et al. Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell 176:1477-1489.e14 (2019). PubMed: 30827683

      Customer reviews and Q&As

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