FITC Anti-DR5 antibody [DR5-01-1] (ab53319)

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Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (ab53319)

    Key features and details

    • FITC Mouse monoclonal [DR5-01-1] to DR5
    • Suitable for: Flow Cyt
    • Reacts with: Human
    • Conjugation: FITC. Ex: 493nm, Em: 528nm
    • Isotype: IgG1

    Conjugates logo Related conjugates and formulations

    APC PE Unconjugated

    Overview

    • Product name

      FITC Anti-DR5 antibody [DR5-01-1]
      See all DR5 primary antibodies

    • Description

      FITC Mouse monoclonal [DR5-01-1] to DR5

    • Host species

      Mouse

    • Conjugation

      FITC. Ex: 493nm, Em: 528nm

    • Tested applications

      Suitable for: Flow Cytmore details

    • Species reactivity

      Reacts with: Human

    • Immunogen

      Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.

    • General notes

      The reagent is free of unconjugated FITC.

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab53319 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Flow Cyt
    Use a concentration of 1 - 5 µg/ml.
    Notes
    Flow Cyt
    Use a concentration of 1 - 5 µg/ml.

    Target

    • Function

      Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

    • Tissue specificity

      Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

    • Involvement in disease

      Squamous cell carcinoma of the head and neck

    • Sequence similarities

      Contains 1 death domain.
      Contains 3 TNFR-Cys repeats.

    • Cellular localization

      Membrane.
    • Information by UniProt

    • Database links

      • Alternative names

        • Fas like protein antibody
        • Apoptosis inducing protein TRICK2A/2B antibody
        • Apoptosis inducing receptor TRAIL R2 antibody
        • CD262 antibody
        • CD262 antigen antibody
        • Cytotoxic TRAIL receptor 2 antibody
        • Death domain containing receptor for TRAIL/Apo 2L antibody
        • Death receptor 5 antibody
        • DR5 antibody
        • KILLER antibody
        • KILLER/DR5 antibody
        • OTTHUMP00000123492 antibody
        • OTTHUMP00000123493 antibody
        • p53 regulated DNA damage inducible cell death receptor(killer) antibody
        • TNF related apoptosis inducing ligand receptor 2 antibody
        • TNF-related apoptosis-inducing ligand receptor 2 antibody
        • TNFRSF10B antibody
        • TR10B_HUMAN antibody
        • TRAIL R2 antibody
        • TRAIL receptor 2 antibody
        • TRAIL-R2 antibody
        • TRAILR2 antibody
        • TRICK2 antibody
        • TRICK2A antibody
        • TRICK2B antibody
        • TRICKB antibody
        • Tumor necrosis factor receptor like protein ZTNFR9 antibody
        • Tumor necrosis factor receptor superfamily member 10B antibody
        • Tumor necrosis factor receptor superfamily, member 10b antibody
        • ZTNFR9 antibody
        see all

      Images

      • Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (ab53319)
        Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (ab53319)

        Flow cytometry analysis (surface staining) of CD262 on CD262-transfectants using ab53319 at 5 μg/ml. 

      References (2)

      Publishing research using ab53319? Please let us know so that we can cite the reference in this datasheet.

      ab53319 has been referenced in 2 publications.

      • Strekalova E  et al. Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction. Methods Mol Biol 1866:61-73 (2019). PubMed: 30725408
      • Pan L  et al. Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell 176:1477-1489.e14 (2019). PubMed: 30827683

      Customer reviews and Q&As

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