FITC Anti-HLA DR + HLA DP antibody [MEM-136] (ab77237)

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Key features and details

  • FITC Mouse monoclonal [MEM-136] to HLA DR + HLA DP
  • Reacts with: Human
  • Conjugation: FITC. Ex: 493nm, Em: 528nm
  • Isotype: IgG1

Overview

  • Product name

    FITC Anti-HLA DR + HLA DP antibody [MEM-136]
    See all HLA DR + HLA DP primary antibodies

  • Description

    FITC Mouse monoclonal [MEM-136] to HLA DR + HLA DP

  • Host species

    Mouse

  • Conjugation

    FITC. Ex: 493nm, Em: 528nm

  • Specificity

    ab77237 recognizes common epitope on beta-chain of human HLA-DR and HLA-DP. It reacts with alpha/beta dimer as well as with dissociated beta-subunit.

  • Species reactivity

    Reacts with: Human

  • Immunogen

    PHA-activated peripheral blood lymphocytes.

  • Positive control

    • Human blood cells.

  • General notes

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.

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Properties

Applications

  • Application notes
    Flow Cyt: Use 20µl for 106 cells or 100µl whole blood.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • Relevance

      Human MHC class II antigens are transmembrane glycoproteins composed of an alpha (36 kDa) and a beta chain (27kDa) and are expressed primarily on antigen presenting cells. Human MHC class II genes are located in the HLA-D region that encodes at least 6 alpha and 10 beta chain genes. Three loci, DR, DQ and DP, encode the major products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells and therefore have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.

    • Cellular localization

      Cell Membrane; Single pass type I membrane protein

    • Database links

      see all

    • Alternative names

      • HLA DP antibody
      • HLA DR antibody
      • MHC Class II antibody

    References (1)

    Publishing research using ab77237? Please let us know so that we can cite the reference in this datasheet.

    ab77237 has been referenced in 1 publication.

    • Koch C  et al. T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density. Int Immunol 11:777-86 (1999). PubMed: 10330283

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