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    fitc-integrin-alpha-2-antibody-ak7-ab30486.pdf

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Signal Transduction Cytoskeleton / ECM Cell Adhesion Integrins Alpha
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FITC Anti-Integrin alpha 2 antibody [AK7] (ab30486)

  • Datasheet
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Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (ab30486)

    Key features and details

    • FITC Mouse monoclonal [AK7] to Integrin alpha 2
    • Suitable for: Flow Cyt
    • Reacts with: Human, Monkey, Baboon, Cynomolgus monkey, Rhesus monkey
    • Conjugation: FITC. Ex: 493nm, Em: 528nm
    • Isotype: IgG1

    You may also be interested in

    Protein
    Product image
    Recombinant Human Integrin alpha 2 protein (ab158772)

    View more associated products

    Overview

    • Product name

      FITC Anti-Integrin alpha 2 antibody [AK7]
      See all Integrin alpha 2 primary antibodies
    • Description

      FITC Mouse monoclonal [AK7] to Integrin alpha 2
    • Host species

      Mouse
    • Conjugation

      FITC. Ex: 493nm, Em: 528nm
    • Specificity

      ab30486 recognises the integrin alpha 2 subunit, which is a 160kD glycoprotein that non covalently associates with the 130kD integrin beta 1 subunit (CD29) to form the VLA2 complex.
    • Tested applications

      Suitable for: Flow Cytmore details
    • Species reactivity

      Reacts with: Human, Monkey, Baboon, Cynomolgus monkey, Rhesus monkey
    • Immunogen

      The details of the immunogen for this antibody are not available.

    • General notes

      Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC).

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C.
    • Storage buffer

      pH: 7.40
      Preservative: 0.09% Sodium azide
      Constituents: PBS, 1% BSA
    • Concentration information loading...
    • Purity

      Protein G purified
    • Clonality

      Monoclonal
    • Clone number

      AK7
    • Myeloma

      NS1
    • Isotype

      IgG1
    • Research areas

      • Signal Transduction
      • Cytoskeleton / ECM
      • Cell Adhesion
      • Integrins
      • Alpha
      • Cancer
      • Cancer Metabolism
      • Response to hypoxia
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Hypoxia
      • Metabolism
      • Types of disease
      • Cancer

    Associated products

    • Alternative Versions

      • PE Anti-Integrin alpha 2 antibody [AK7] (ab230470)
      • FITC Anti-Integrin alpha 2 antibody [AK7] (ab234158)
      • Anti-Integrin alpha 2 antibody [AK7] (ab30487)
    • Isotype control

      • FITC Mouse IgG1 [B11/6] - Isotype Control (ab91356)
    • Recombinant Protein

      • Recombinant Human Integrin alpha 2 protein (ab158772)

    Applications

    Our Abpromise guarantee covers the use of ab30486 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Flow Cyt
  • Application notes
    Flow Cyt: 1/Neat - 1/5. Use 10µl of the working dilution for 106 cells or 100ul whole blood.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
    • Sequence similarities

      Belongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
      Contains 1 VWFA domain.
    • Domain

      The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession P17301 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 3673 Human
      • Omim: 192974 Human
      • SwissProt: P17301 Human
      • Unigene: 482077 Human
      • Alternative names

        • BR antibody
        • CD 49b antibody
        • CD49 antigen like family member B antibody
        • CD49 antigen-like family member B antibody
        • CD49b antibody
        • CD49b antigen antibody
        • Collagen receptor antibody
        • DX5 antibody
        • Glycoprotein Ia deficiency included antibody
        • GP Ia antibody
        • GP Ia deficiency, included antibody
        • GPIa antibody
        • HPA 5 included antibody
        • HPA5 included antibody
        • Human platelet alloantigen system 5 antibody
        • Integrin alpha 2 antibody
        • Integrin alpha II antibody
        • Integrin alpha-2 antibody
        • Integrin, alpha 2 (CD49B alpha 2 subunit of VLA 2 receptor) antibody
        • ITA2_HUMAN antibody
        • ITGA2 antibody
        • Platelet alloantigen Br(a), included antibody
        • Platelet antigen Br antibody
        • Platelet glycoprotein GPIa antibody
        • Platelet glycoprotein Ia antibody
        • Platelet glycoprotein Ia/IIa antibody
        • Platelet membrane glycoprotein Ia antibody
        • Platelet receptor for collagen, deficiency of, included antibody
        • Very late activation protein 2 receptor alpha 2 subunit antibody
        • VLA 2 alpha chain antibody
        • VLA 2 antibody
        • VLA 2 subunit alpha antibody
        • VLA-2 subunit alpha antibody
        • VLA2 antibody
        • VLA2 receptor alpha 2 subunit antibody
        • VLAA2 antibody
        see all

      Images

      • Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (ab30486)
        Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (ab30486)
        Flow cytometric analysis of human peripheral blood platlets with 10µl for 106 cells of anti human CD49b FITC conjugated (ab30486).

      Protocols

      • Flow cytometry protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (3)

      Publishing research using ab30486? Please let us know so that we can cite the reference in this datasheet.

      ab30486 has been referenced in 3 publications.

      • Hellevik T  et al. Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced. Radiat Oncol 7:59 (2012). Flow Cyt ; Human . PubMed: 22500976
      • Ingenito EP  et al. Autologous lung-derived mesenchymal stem cell transplantation in experimental emphysema. Cell Transplant 21:175-89 (2012). PubMed: 21294955
      • Ingenito EP  et al. Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung. J Tissue Eng Regen Med 4:259-72 (2010). PubMed: 20020503

      Customer reviews and Q&As

      Show All Reviews Q&A
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      There are currently no Customer reviews or Questions for ab30486.
      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com

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