FITC Anti-Integrin alpha 2 antibody [AK7] (ab30486)
![Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (ab30486)](https://www.abcam.com/ps/products/30/ab30486/Images/ab30486-40435-anti-integrin-alpha-2-antibody-ak7-fitc-flow-cytometry.jpg "Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (ab30486)")
Key features and details
- FITC Mouse monoclonal [AK7] to Integrin alpha 2
- Suitable for: Flow Cyt
- Reacts with: Human, Monkey, Baboon, Cynomolgus monkey, Rhesus monkey
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
Overview
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Product name
FITC Anti-Integrin alpha 2 antibody [AK7]
See all Integrin alpha 2 primary antibodies -
Description
FITC Mouse monoclonal [AK7] to Integrin alpha 2 -
Host species
Mouse -
Conjugation
FITC. Ex: 493nm, Em: 528nm -
Specificity
ab30486 recognises the integrin alpha 2 subunit, which is a 160kD glycoprotein that non covalently associates with the 130kD integrin beta 1 subunit (CD29) to form the VLA2 complex. -
Tested applications
Suitable for: Flow Cytmore details -
Species reactivity
Reacts with: Human, Monkey, Baboon, Cynomolgus monkey, Rhesus monkey -
Immunogen
The details of the immunogen for this antibody are not available.
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General notes
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC).
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
AK7 -
Myeloma
NS1 -
Isotype
IgG1 -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab30486 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Flow Cyt |
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. -
Sequence similarities
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
Domain
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3673 Human
- Omim: 192974 Human
- SwissProt: P17301 Human
- Unigene: 482077 Human
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Alternative names
- BR antibody
- CD 49b antibody
- CD49 antigen like family member B antibody
see all
Images
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Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (ab30486)Flow cytometric analysis of human peripheral blood platlets with 10µl for 106 cells of anti human CD49b FITC conjugated (ab30486).
Datasheets and documents
References (3)
ab30486 has been referenced in 3 publications.
- Hellevik T et al. Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced. Radiat Oncol 7:59 (2012). Flow Cyt ; Human . PubMed: 22500976
- Ingenito EP et al. Autologous lung-derived mesenchymal stem cell transplantation in experimental emphysema. Cell Transplant 21:175-89 (2012). PubMed: 21294955
- Ingenito EP et al. Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung. J Tissue Eng Regen Med 4:259-72 (2010). PubMed: 20020503
