FITC Anti-MD2 antibody [18H10] (ab106105)

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Key features and details

  • FITC Mouse monoclonal [18H10] to MD2
  • Reacts with: Human
  • Conjugation: FITC. Ex: 493nm, Em: 528nm
  • Isotype: IgG2b

Overview

  • Product name

    FITC Anti-MD2 antibody [18H10]
    See all MD2 primary antibodies

  • Description

    FITC Mouse monoclonal [18H10] to MD2

  • Host species

    Mouse

  • Conjugation

    FITC. Ex: 493nm, Em: 528nm

  • Specificity

    ab106105 reacts with MD2. However, it does not react with sMD2.

  • Species reactivity

    Reacts with: Human

  • Immunogen

    TLR4/MD2 expressing CHO cells/ chimeric TLR4/MD2 fusion protein

  • General notes


    The monoclonal antibody 18H10 is able to inhibit bacterial binding to MD2.

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

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    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid

  • Storage instructions

    Shipped at 4°C. Store at +4°C.

  • Storage buffer

    Constituents: 1% BSA, PBS
  • Concentration information loading...

  • Purity

    Protein G purified

  • Primary antibody notes

    The monoclonal antibody 18H10 is able to inhibit bacterial binding to MD2.

  • Clonality

    Monoclonal

  • Clone number

    18H10

  • Isotype

    IgG2b

  • Research areas

Target

  • Function

    Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.

  • Post-translational
    modifications

    N-glycosylated; high-mannose.

  • Cellular localization

    Secreted > extracellular space.
  • Information by UniProt

  • Database links

    • Alternative names

      • ESOP 1 antibody
      • ESOP-1 antibody
      • ESOP1 antibody
      • LY 96 antibody
      • Ly-96 antibody
      • LY96 antibody
      • LY96_HUMAN antibody
      • Lymphocyte antigen 96 antibody
      • md 2 antibody
      • MD 2 protein antibody
      • MD2 protein antibody
      • Myeloid differentiation protein 2 antibody
      • Protein MD 2 antibody
      • Protein MD-2 antibody
      • Protein MD2 antibody
      see all

    References (0)

    Publishing research using ab106105? Please let us know so that we can cite the reference in this datasheet.

    ab106105 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Question

    Could you provide the Flow cytometry image data please?

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    Answer

    Thank you for your enquiry.

    This antibody to MD-2, clone 18H10, has been extensively published. For flow cytometry data please refer to the 4 publications below.


    1. Pugin, J et al; Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood 2004, 104: 4071
    [ [Figure 6, http://bloodjournal.hematologylibrary.org/content/104/13/4071.full.html]

    2. Daubeuf, B et al; TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock. J Immunol 2007, 179: 6107
    [Figure 2, http://www.jimmunol.org/content/179/9/6107.full.pdf]


    3. Elson, G et al; Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria. Blood 2007, 109: 1574
    [Figure 2, http://bloodjournal.hematologylibrary.org/content/109/4/1574.full.pdf]

    4. Tissieres, P et al; Soluble MD-2 is an acute phase protein and an opsonin for Gram-negative bacteria. Blood 2008, 111: 2122
    [Figure 5, http://bloodjournal.hematologylibrary.org/content/111/4/2122.full]


    I hope this information will be helpful.

    Have a nice day!

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