FITC Anti-Mitofusin 2 antibody [N153/5] (ab186319)
Key features and details
- FITC Mouse monoclonal [N153/5] to Mitofusin 2
- Reacts with: Mouse
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG2a
Overview
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Product name
FITC Anti-Mitofusin 2 antibody [N153/5]
See all Mitofusin 2 primary antibodies -
Description
FITC Mouse monoclonal [N153/5] to Mitofusin 2 -
Host species
Mouse -
Conjugation
FITC. Ex: 493nm, Em: 528nm -
Specificity
ab186319 does not cross react with Mitofusin 1. -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat, Human
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Immunogen
Recombinant fragment corresponding to Mouse Mitofusin 2 aa 370-600.
Database link: Q80U63 -
Positive control
- Mouse cardiac mitochondrial lysate.
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General notes
The clone number has been updated from S153-5 to N153/5, both clone numbers name the same antibody clone.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. Store In the Dark. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
N153/5 -
Isotype
IgG2a -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Recombinant Protein
Target
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Function
Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions. -
Tissue specificity
Ubiquitous; expressed at low level. Highly expressed in heart and kidney. -
Involvement in disease
Charcot-Marie-Tooth disease 2A2
Neuropathy, hereditary motor and sensory, 6A -
Sequence similarities
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.
Contains 1 dynamin-type G (guanine nucleotide-binding) domain. -
Post-translational
modificationsPhosphorylated by PINK1.
Ubiquitinated by non-degradative ubiquitin by PARK2, promoting mitochondrial fusion; deubiquitination by USP30 inhibits mitochondrial fusion. -
Cellular localization
Mitochondrion outer membrane. Colocalizes with BAX during apoptosis. - Information by UniProt
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Database links
- Entrez Gene: 9927 Human
- Entrez Gene: 170731 Mouse
- Entrez Gene: 64476 Rat
- Omim: 608507 Human
- SwissProt: O95140 Human
- SwissProt: Q80U63 Mouse
- SwissProt: Q8R500 Rat
- Unigene: 376681 Human
see all -
Alternative names
- CMT2A antibody
- CMT2A2 antibody
- CPRP 1 antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (0)
ab186319 has not yet been referenced specifically in any publications.
