Key features and details
- FITC Mouse monoclonal [2C1.3A11] to Nestin
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
Product nameFITC Anti-Nestin antibody [2C1.3A11]
See all Nestin primary antibodies
DescriptionFITC Mouse monoclonal [2C1.3A11] to Nestin
ConjugationFITC. Ex: 493nm, Em: 528nm
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human Nestin. 150 amino acids.
Database link: P48681
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Storage instructionsShipped at 4°C. Store at +4°C. Store In the Dark.
Storage bufferPreservative: 0.09% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityProtein G purified
FunctionRequired for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.
Tissue specificityCNS stem cells.
Sequence similaritiesBelongs to the intermediate filament family.
Developmental stageUpon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments.
modificationsConstitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized.
- Information by UniProt
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ab187846 has been referenced in 1 publication.
- Guo YH et al. Effects of ginsenoside Rg1-loaded alginate-chitosan microspheres on human bone marrow stromal cells. Biosci Rep 37:N/A (2017). PubMed: 28536312