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    fitc-sirp-alpha-antibody-ox-41-ab34076.pdf

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Neuroscience Cell Adhesion Proteins ECM Proteins
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FITC Anti-SIRP alpha antibody [OX-41] (ab34076)

  • Datasheet
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Key features and details

  • FITC Mouse monoclonal [OX-41] to SIRP alpha
  • Reacts with: Rat
  • Conjugation: FITC. Ex: 493nm, Em: 528nm
  • Isotype: IgG2a

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Protein
Product image
Recombinant human SIRP alpha protein (Fc Chimera Active) (ab221342)

View more associated products

Overview

  • Product name

    FITC Anti-SIRP alpha antibody [OX-41]
    See all SIRP alpha primary antibodies
  • Description

    FITC Mouse monoclonal [OX-41] to SIRP alpha
  • Host species

    Mouse
  • Conjugation

    FITC. Ex: 493nm, Em: 528nm
  • Species reactivity

    Reacts with: Rat
  • Immunogen

    Peritoneal macrophages (Rat)

  • Epitope

    ab34076 binds to a different epitope on SIRP than ab34079, ab34081 and ab34086.
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    pH: 7.40
    Preservative: 0.09% Sodium azide
    Constituents: PBS, 1% BSA
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Monoclonal
  • Clone number

    OX-41
  • Myeloma

    NS0/U
  • Isotype

    IgG2a
  • Research areas

    • Neuroscience
    • Cell Adhesion Proteins
    • ECM Proteins
    • Neuroscience
    • Neurology process
    • Neural Signal Transduction
    • Neuroscience
    • Cell Type Marker
    • Neuron marker
    • Synapse marker
    • Cardiovascular
    • Atherosclerosis
    • Vascular Inflammation
    • Inflammatory mediators

Associated products

  • Alternative Versions

    • Biotin Anti-SIRP alpha antibody [OX-41] (ab33987)
  • Isotype control

    • FITC Mouse IgG2a, kappa monoclonal [MOPC-173] - isotype control (ab18455)
  • Recombinant Protein

    • Recombinant human SIRP alpha protein (Fc Chimera Active) (ab221342)

Applications

  • Application notes
    Flow Cyt: Use at an assay dependent dilution. Use 10µl dilution for 106 cells in 100ul.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
    • Tissue specificity

      Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
    • Sequence similarities

      Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Post-translational
      modifications

      N-glycosylated.
      Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession P78324 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 25528 Rat
      • SwissProt: P97710 Rat
      • Unigene: 53971 Rat
      • Alternative names

        • Signal regulatory protein alpha type 1 antibody
        • Bit antibody
        • Brain Ig like molecule with tyrosine based activation motifs antibody
        • Brain Ig-like molecule with tyrosine-based activation motifs antibody
        • Brain immunoglobulin like molecule with tyrosine based activation motifs antibody
        • CD172 antigen like family member A antibody
        • CD172 antigen-like family member A antibody
        • CD172a antibody
        • CD172a antigen antibody
        • Inhibitory receptor SHPS-1 antibody
        • Macrophage fusion receptor antibody
        • MFR antibody
        • MYD 1 antibody
        • Myd 1 antigen antibody
        • MyD-1 antigen antibody
        • p84 antibody
        • Protein tyrosine phosphatase non receptor type substrate 1 antibody
        • PTPNS1 antibody
        • SHP substrate 1 antibody
        • SHPS-1 antibody
        • SHPS1 antibody
        • SHPS1_HUMAN antibody
        • Signal regulatory protein alpha 2 antibody
        • Signal regulatory protein alpha 3 antibody
        • Signal regulatory protein alpha antibody
        • Signal regulatory protein alpha type 2 antibody
        • Signal-regulatory protein alpha-1 antibody
        • Signal-regulatory protein alpha-2 antibody
        • Signal-regulatory protein alpha-3 antibody
        • SIRP antibody
        • Sirp-alpha-1 antibody
        • Sirp-alpha-2 antibody
        • Sirp-alpha-3 antibody
        • SIRPA antibody
        • SIRPalpha antibody
        • SIRPalpha1 antibody
        • SIRPalpha2 antibody
        • SIRPalpha3 antibody
        • Tyrosine phosphatase SHP substrate 1 antibody
        • Tyrosine protein phosphatase non receptor type substrate 1 antibody
        • Tyrosine-protein phosphatase non-receptor type substrate 1 antibody
        see all

      Protocols

      • Flow cytometry protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab34076? Please let us know so that we can cite the reference in this datasheet.

      ab34076 has not yet been referenced specifically in any publications.

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