FITC Anti-TLR6 antibody [TLR6.127] (ab72362)

Submit a review Q&A (2)References (1)

Key features and details

  • FITC Mouse monoclonal [TLR6.127] to TLR6
  • Reacts with: Human
  • Conjugation: FITC. Ex: 493nm, Em: 528nm
  • Isotype: IgG1

Overview

  • Product name

    FITC Anti-TLR6 antibody [TLR6.127]
    See all TLR6 primary antibodies

  • Description

    FITC Mouse monoclonal [TLR6.127] to TLR6

  • Host species

    Mouse

  • Conjugation

    FITC. Ex: 493nm, Em: 528nm

  • Species reactivity

    Reacts with: Human

  • Immunogen

    BALB/c mice were immunized with Ba/F3 cells that stably expressed human Myc-tagged TLR6.

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

Target

  • Function

    Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.

  • Tissue specificity

    Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

  • Sequence similarities

    Belongs to the Toll-like receptor family.
    Contains 12 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.

  • Cellular localization

    Cell membrane. Cytoplasmic vesicle > phagosome membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • CD286 antibody
      • CD286 antigen antibody
      • TLR 6 antibody
      • Tlr6 antibody
      • TLR6_HUMAN antibody
      • Toll like receptor 6 precursor antibody
      • Toll-like receptor 6 antibody
      see all

    References (1)

    Publishing research using ab72362? Please let us know so that we can cite the reference in this datasheet.

    ab72362 has been referenced in 1 publication.

    • Nakstad B  et al. Early detection of neonatal group B streptococcus sepsis and the possible diagnostic utility of IL-6, IL-8, and CD11b in a human umbilical cord blood in vitro model. Infect Drug Resist 9:171-9 (2016). Flow Cyt . PubMed: 27468243

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-2 of 2 Abreviews or Q&A

    Question

    To whomever this may concern,
    I am interested in finding out the immunogen sequences for your antibodies Ab72362, Ab58864, and Ab16892 as they are not listed on your website. Do you have this information?

    Read More
    Answer

    Thank you for your inquiry.

    The products ab16892 and ab58864 are both from the same clone [5G5] and have the same immunogen: Purified fusion protein of extracellular domain of human TLR9 (AA 1-815) and human IgGFc.The immunogen for both is as described in the paper below:

    Ahmad-Nejad, P et al; Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol 2002, 32: 1958

    Regarding ab72362, the immunogen is BALB/c mice immunized with Ba/F3 cells that stably expressed human Myc-tagged TLR6. The epitope has not been mapped.
    I hope this information helps. Please contact us with any other questions.

    Read More

    Question

    To whomever this may concern,

    I am writing to inquire about your following products Ab72362, Ab22046, Ab58864
    and Ab16892.
    We are planning on completing Flow Cytometry on bovine blood mononuclear cells
    in order to quantify the expression of TLRs 2, 4, 6 and 9. We have already found
    a bovine-specific antibody for TLR2, but are still looking for antibodies to the
    other TLRs.
    We are interested if you have tested and proved the cross reactivity of your
    products above for bovine. If you have, or if you have other products that
    would be suitable, please let us know. If you have not, we were hoping to get a
    small aliquot of these antibodies in order to test them for cross reactivity to
    bovine ourselves.

    Read More
    Answer

    Thank you very much for your interest in our products.

    To our knowledge,none of our TLR6 or TLR9 antibodies havebeen tested in bovine. Since we have over 90,000 products we cannot store multiple vial sizes for testing. Therefore, I can offer a discount off a future purchase if you buyanti-TLR6 and anti-TLR9antibodies now, test them inbovine and submit feedback to us in the form of an Abreview. It doesn’t matter whether the Abreview is positive or negative, we would just really like to receive your feedback. The discount would be to the value of: 1 free primary antibody per antibody tested.

    If you are interested in this offer, please follow these steps:

    1. Reply to this e-mail to let me know that you would like to proceedand let me know the catalogue number of the product/s youwould like to testin bovine. I will then send thediscount code/s.The codesmust be issued before purchasing the antibodies so please wait for my reply before ordering.

    2. Purchasethe antibodyeither by phone, fax, or online (www.abcam.com).

    3. Test it in bovine.

    4. Let us know the results, positive or negative, using our Abreview system (this will take about 10 minutes and images are great if you have them!). To find out how to submit an Abreview, please visit: https://www.abcam.com/abreviews.

    5. After the review is submitted to us, the discount code becomes active. Simply place your new order by phone, fax, or on the web and mention the discount code. The discount can be redeemed for any primary antibody ordered and the discount code is valid for 4 months after issue.
    Please remember that submission of the Abreview is sufficient for the discount code to become active.

    We are always pleased to obtain feedback about our products and any information is greatly appreciated! Even ifthe antibodyturns out to be unsuitable for bovine, you will still receive the discount on your next purchase after your Abreview has been submitted.

    Please let me know if you have any questions about this offer and I would be happy to help you further.

    The Terms and Conditions of this offer can be found at: https://www.abcam.com/collaborationdiscount.

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com