Question (73149) | FK506 (Tacrolimus), Immunosuppressant (ab120223)

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Question

Dear, I am interested in buying FK506 (tacrolimus) from your company. The goal would be to administer FK506 or vehicle via IP injections to mice. As a vehicle I would like to use saline. However, do you have any data or literature about the solubility of your FK506 in saline? Kind regards

Answer

Thank you for your enquiry and interest in our products.
We tested to see if this product could be dissolved in saline, however it could not be solubilised.
It is known that FK506 (Tacrolimus) is soluble to around 100 mM in ethanol.
I would suggest reading through the literature as this paper has used a combination of saline, PEG40 castor oil and 2% ethanol to use FK506: https://www.ncbi.nlm.nih.gov/pubmed/28083805 I hope this will be useful for you. If you need any further assistance in the future, please do not hesitate to contact me.

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