Product nameFKBP38 peptide
Our Abpromise guarantee covers the use of ab51928 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: 0.1% BSA, PBS, pH 7.2
- 38 kDa FK506-binding protein
- 38 kDa FKBP
FunctionConstitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Tissue specificityWidely expressed. Highest levels seen in the brain.
Sequence similaritiesContains 1 PPIase FKBP-type domain.
Contains 3 TPR repeats.
Cellular localizationMitochondrion membrane.
- Information by UniProt
ab51928 has not yet been referenced specifically in any publications.