Key features and details
- Goat polyclonal to FKBP52
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-FKBP52 antibody
See all FKBP52 primary antibodies
DescriptionGoat polyclonal to FKBP52
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
- Human Brain (Cerebellum) and Human Kidney tissue. Human Placenta lysate
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab110191 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 52 kDa.|
|IHC-P||Use a concentration of 3.75 µg/ml.|
FunctionImmunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.
Tissue specificityWidely expressed.
Sequence similaritiesContains 2 PPIase FKBP-type domains.
Contains 3 TPR repeats.
DomainThe PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).
The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.
The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.
modificationsPhosphorylation by CK2 results in loss of HSP90 binding activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationCytoplasm > cytosol. Nucleus. Cytoplasm > cytoskeleton.
- Information by UniProt
- 51 kDa FK506-binding protein antibody
- 52 kDa FK506 binding protein antibody
- 52 kDa FK506-binding protein antibody
ab110191, at 3.75 µg/ml, staining FKBP52 in formalin-fixed, paraffin-embedded Human Brain (Cerebellum) tissue by Immunohistochemistry.
ab110191, at 3.75 µg/ml, staining FKBP52 in formalin-fixed, paraffin-embedded Human kidney tissue by Immunohistochemistry.
Anti-FKBP52 antibody (ab110191) at 0.01 µg/ml + Human Placenta lysate at 35 µg
Developed using the ECL technique.
Predicted band size: 52 kDa
Primary incubation was 1 hour.
ab110191 has not yet been referenced specifically in any publications.