Overview

  • Product name

    Flavokawain A, Chalcone from kava
  • Description

    Chalcone from kava. Apoptotic agent.
  • Biological description

    Chalcone from kava. Decreases cyclin dependent kinase-2 (CDK2) inducing G2-M arrest in vitro. Antiproliferative and apoptotic effects.
  • Purity

    > 99%
  • CAS Number

    64680-84-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one
  • Molecular weight

    314.34
  • Molecular formula

    C18H18O5
  • PubChem identifier

    5355469
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC=C(C=C1)/C=C/C(=O)C2=C(C=C(C=C2OC)OC)O
  • Source

    Piper methysticum

  • Research areas

References

This product has been referenced in:

  • Tang Y  et al. Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53. Cancer Prev Res (Phila) 1:439-51 (2008). Read more (PubMed: 19138991) »
  • Zi X & Simoneau AR Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res 65:3479-86 (2005). Read more (PubMed: 15833884) »

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