Overview

  • Product name

    Flavokawain B, chalcone isolated from kava
  • Description

    Naturally occuring chalcone isolated from kava
  • Biological description

    A naturally occuring chalcone isolated from kava. Potent hepatocellular toxin. Induces apoptosis and cell-cycle arrest and demonstrates anti-inflammatory and anti-nociceptive activity.
  • Purity

    > 97%
  • CAS Number

    1775-97-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
  • Molecular weight

    284.31
  • Molecular formula

    C17H16O4
  • PubChem identifier

    5356121
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 35 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC(=C(C(=C1)OC)C(=O)C=CC2=CC=CC=C2)O
  • Source

    Piper methysticum

  • Research areas

References

This product has been referenced in:

  • Hseu YC  et al. The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway. J Agric Food Chem 60:2385-97 (2012). Read more (PubMed: 22324429) »
  • Mohamad AS  et al. Possible participation of nitric oxide/cyclic guanosine monophosphate/protein kinase C/ATP-sensitive K(+) channels pathway in the systemic antinociception of flavokawin B. Basic Clin Pharmacol Toxicol 108:400-5 (2011). Read more (PubMed: 21214864) »
  • Zhou P  et al. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. FASEB J 24:4722-32 (2010). Read more (PubMed: 20696856) »

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