Flavopiridol hydrochloride, CDK and CDC25 phosphatase inhibitor (ab141300)
Key features and details
- Potent CDK and CDC25 phosphatase inhibitor
- CAS Number: 131740-09-5
- Purity: > 99%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Flavopiridol hydrochloride, CDK and CDC25 phosphatase inhibitor -
Description
Potent CDK and CDC25 phosphatase inhibitor -
Biological description
Potent ATP-competitive CDK and CDC25 phosphatase inhibitor (IC50 values are 40, 40, 40, 40 and 300 nM for CDK1,2,4,6 and 7 respectively). Inhibits EGFR and PKA (IC50 values are 21 and 122 μM respectively). Induces cell cycle arrest at G1 and G2 phase. Shows potent antiproliferative effects in cancer cell lines (IC50 = 25 - 160 nM, breast and lung cancer cells). Shows antitumor effects in vivo. -
Purity
> 99% -
CAS Number
131740-09-5 -
Chemical structure
Properties
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Chemical name
2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one hydrochloride -
Molecular weight
438.30 -
Molecular formula
C21H20ClNO5.HCl -
PubChem identifier
9910986 -
Storage instructions
Store at +4°C. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (0)
ab141300 has not yet been referenced specifically in any publications.