Flavopiridol hydrochloride, CDK and CDC25 phosphatase inhibitor (ab141300)
- Datasheet
- References
Overview
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Product name
Flavopiridol hydrochloride, CDK and CDC25 phosphatase inhibitor -
Description
Potent CDK and CDC25 phosphatase inhibitor -
Biological description
Potent ATP-competitive CDK and CDC25 phosphatase inhibitor (IC50 values are 40, 40, 40, 40 and 300 nM for CDK1,2,4,6 and 7 respectively). Inhibits EGFR and PKA (IC50 values are 21 and 122 μM respectively). Induces cell cycle arrest at G1 and G2 phase. Shows potent antiproliferative effects in cancer cell lines (IC50 = 25 - 160 nM, breast and lung cancer cells). Shows antitumor effects in vivo. -
Purity
> 99% -
CAS Number
131740-09-5 -
Chemical structure
Properties
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Chemical name
2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one hydrochloride -
Molecular weight
438.30 -
Molecular formula
C21H20ClNO5.HCl -
PubChem identifier
9910986 -
Storage instructions
Store at +4°C. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Bianco MR et al. Cross-talk between cell cycle induction and mitochondrial dysfunction during oxidative stress and nerve growth factor withdrawal in differentiated PC12 cells. J Neurosci Res 89:1302-15 (2011). Read more (PubMed: 21557293) »
- De Azevedo WF et al. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc Natl Acad Sci U S A 93:2735-40 (1996). Read more (PubMed: 8610110) »
- Dannenfelser RM et al. Parenteral formulation of Flavopiridol (NSC-649890). PDA J Pharm Sci Technol 50:356-9 (0). Read more (PubMed: 9038080) »
