Flavopiridol hydrochloride, CDK and CDC25 phosphatase inhibitor (ab141300)

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Key features and details

  • Potent CDK and CDC25 phosphatase inhibitor
  • CAS Number: 131740-09-5
  • Purity: > 99%
  • Soluble in water to 100 mM and in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Flavopiridol hydrochloride, CDK and CDC25 phosphatase inhibitor

  • Description

    Potent CDK and CDC25 phosphatase inhibitor

  • Biological description

    Potent ATP-competitive CDK and CDC25 phosphatase inhibitor (IC50 values are 40, 40, 40, 40 and 300 nM for CDK1,2,4,6 and 7 respectively). Inhibits EGFR and PKA (IC50 values are 21 and 122 μM respectively). Induces cell cycle arrest at G1 and G2 phase. Shows potent antiproliferative effects in cancer cell lines (IC50 = 25 - 160 nM, breast and lung cancer cells). Shows antitumor effects in vivo.

  • Purity

    > 99%

  • CAS Number

    131740-09-5

  • Chemical structure

    Chemical Structure

Properties

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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References (0)

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ab141300 has not yet been referenced specifically in any publications.

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