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    flavopiridol-hydrochloride-cdk-and-cdc25-phosphatase-inhibitor-ab141300.pdf

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Cardiovascular Angiogenesis Cytokines Other
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Flavopiridol hydrochloride, CDK and CDC25 phosphatase inhibitor (ab141300)

  • Datasheet
  • SDS
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Key features and details

  • Potent CDK and CDC25 phosphatase inhibitor
  • CAS Number: 131740-09-5
  • Purity: > 99%
  • Soluble in water to 100 mM and in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Flavopiridol hydrochloride, CDK and CDC25 phosphatase inhibitor
  • Description

    Potent CDK and CDC25 phosphatase inhibitor
  • Biological description

    Potent ATP-competitive CDK and CDC25 phosphatase inhibitor (IC50 values are 40, 40, 40, 40 and 300 nM for CDK1,2,4,6 and 7 respectively). Inhibits EGFR and PKA (IC50 values are 21 and 122 μM respectively). Induces cell cycle arrest at G1 and G2 phase. Shows potent antiproliferative effects in cancer cell lines (IC50 = 25 - 160 nM, breast and lung cancer cells). Shows antitumor effects in vivo.
  • Purity

    > 99%
  • CAS Number

    131740-09-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one hydrochloride
  • Molecular weight

    438.30
  • Molecular formula

    C21H20ClNO5.HCl
  • PubChem identifier

    9910986
  • Storage instructions

    Store at +4°C.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
  • Source

    Synthetic

  • Research areas

    • Cardiovascular
    • Angiogenesis
    • Cytokines
    • Other
    • Immunology
    • Adaptive Immunity
    • MHC
    • Class I
    • Immunology
    • Innate Immunity
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    • Interferons
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Synthesis
    • Topoisomerases
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Domain Families
    • Zinc Finger
    • Cell Biology
    • Apoptosis
    • Intracellular
    • Caspases etc
    • Caspases
    • Neuroscience
    • Neurology process
    • Neural Signal Transduction
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • Nuclear Hormone Receptors
    • Estrogen
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • Nuclear Hormone Receptors
    • Corticoid
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • Nuclear Hormone Receptors
    • Testosterone
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • Nuclear Hormone Receptors
    • Retinoic & Retinoid
    • Signal Transduction
    • Growth Factors/Hormones
    • Hormones
    • Cell Biology
    • Cell Cycle
    • Cell differentiation
    • Neuroscience
    • Endocrine system
    • Gonadotrophic axis
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Corticoid
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Estrogen
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Retinoic & Retinoid
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Testosterone
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Transcription Factors
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Orphan Nuclear Receptors
    • Signal Transduction
    • Metabolism
    • Drug metabolism
    • Stem Cells
    • Signaling Pathways
    • Hedgehog
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    • Invasion/microenvironment
    • Apoptosis
    • Caspases
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    • Signal transduction
    • Nuclear signaling
    • Nuclear hormone receptors
    • Estrogen
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    • Signal transduction
    • Nuclear signaling
    • Nuclear hormone receptors
    • Retanoic and retanoid
    • Cancer
    • Signal transduction
    • Nuclear signaling
    • Nuclear hormone receptors
    • Other
    • Cancer
    • Tumor immunology
    • Cytokines
    • Interferons
    • Cell Biology
    • Proteolysis / Ubiquitin
    • Proteolytic enzymes
    • Other proteases
    • Cancer
    • Tumor biomarkers
    • Receptors
    • Developmental Biology
    • Reproduction
    • Hormones
    • Cancer
    • Cancer Metabolism
    • Metabolic signaling pathway
    • Metabolism of lipids and lipoproteins
    • Cancer
    • Cancer Metabolism
    • Metabolic signaling pathway
    • Hormone biosynthesis
    • Biochemicals
    • Product Range
    • New
    • Biochemicals
    • Product Range
    • Just Add Water
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Enzymes
    • Kinase
    • Cyclin-dependent kinase
    • Inhibitors
    • Metabolism
    • Pathways and Processes
    • Mitochondrial Metabolism
    • Mitochondrial Biogenesis
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Nucleotide metabolism
    • Molecular processes
    • Mitochondrial transcription
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipid metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Drug metabolism
    • Metabolism
    • Pathways and Processes
    • Endocrine metabolism
    • Hormone biosynthesis
    • Metabolism
    • Pathways and Processes
    • Metabolism processes
    • Apoptosis
    • Biochemicals
    • Pharmacology
    • Signaling
    • Apoptosis & cell cycle
    • Cyclin-dependent kinase
    • Inhibitors
    • Biochemicals
    • Pharmacology
    • Enzymes
    • Phosphatase
    • cdc25
    • Inhibitors
    • Cancer
    • Cell Death
    • Apoptosis
    • Apoptosis Markers
    • Caspases
    • Cancer
    • Cell Death
    • Apoptosis
    • Metabolism

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab141300? Please let us know so that we can cite the reference in this datasheet.

    ab141300 has not yet been referenced specifically in any publications.

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