Flecainide, Sodium channel blocker (ab120504)
Key features and details
- Sodium channel blocker
- CAS Number: 54143-55-4
- Soluble in ethanol to 100 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Flecainide, Sodium channel blocker -
Description
Sodium channel blocker -
Biological description
Sodium channel blocker. Class IC antiarrhythmic agent. Inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Also inhibits cardiac ryanodine receptors. Orally-active.
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CAS Number
54143-55-4 -
Chemical structure
Properties
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Chemical name
(RS)-N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide -
Molecular weight
414.34 -
Molecular formula
C17H20F6N2O3 -
PubChem identifier
3356 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
FC(F)(F)COc2cc(C(=O)NCC1CCCCN1)c(OCC(F)(F)F)cc2 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab120504 has been referenced in 2 publications.
- Jæger KH et al. Identifying Drug Response by Combining Measurements of the Membrane Potential, the Cytosolic Calcium Concentration, and the Extracellular Potential in Microphysiological Systems. Front Pharmacol 11:569489 (2020). PubMed: 33628168
- Streit J & Kleinlogel S Dynamic all-optical drug screening on cardiac voltage-gated ion channels. Sci Rep 8:1153 (2018). PubMed: 29348631