Overview

  • Product name

    Florfenicol, Antibacterial agent
  • Description

    Antibacterial agent
  • Biological description

    Antibacterial agent. Synthetic fluorinated derivative of thiamphenicol. Inhibits 70S ribosomal activity and downstream protein synthesis. Pharmacologically active following oral administration.
  • Purity

    > 99%
  • CAS Number

    73231-34-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
  • Molecular weight

    358.21
  • Molecular formula

    C12H14Cl2FNO4S
  • PubChem identifier

    5201447
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=S(C)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zhao HY  et al. Pharmacokinetics of florfenicol in crucian carp (Carassius auratus cuvieri) after a single intramuscular or oral administration. J Vet Pharmacol Ther 34:460-3 (2011). Read more (PubMed: 21443750) »
  • Schwarz S  et al. Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS Microbiol Rev 28:519-42 (2004). Read more (PubMed: 15539072) »
  • Ho SP  et al. Antibacterial effect of chloramphenicol, thiamphenicol and florfenicol against aquatic animal bacteria. J Vet Med Sci 62:479-85 (2000). Read more (PubMed: 10852395) »

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