Overview

  • Product name

    Flubendazole, antiprolifereative agent.
  • Description

    Potent anthelmintic agent. Antiprolifereative agent.
  • Biological description

    Potent athelmintic agent (IC50 = 3 nM, MDAY-D2 cells). Antiproliferative agent (IC50 = 0.9 μM). Induces cell cycle arrest in the G2/M phase. Shows mutagenic effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    31430-15-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
  • Molecular weight

    313.28
  • Molecular formula

    C16H12FN3O3
  • PubChem identifier

    35802
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 1 mg/mL
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(C(=O)C2=CC3=C(C=C2)N=C(N3)NC(=O)OC)=CC=C(C=C1)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ermler S  et al. Genotoxic mixtures and dissimilar action: concepts for prediction and assessment. Arch Toxicol 88:799-814 (2014). Read more (PubMed: 24297155) »
  • Králová V  et al. Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines. Anticancer Drugs 24:911-9 (2013). Read more (PubMed: 23884106) »
  • Kan CA  et al. Flubendazole residues in eggs after oral administration to laying hens: determination with reversed phase liquid chromatography. Analyst 123:2525-7 (1998). Read more (PubMed: 10435292) »

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