Overview

  • Product name

    Fludarabine (FAMP), DNA synthesis inhibitor
  • Description

    DNA synthesis inhibitor. Prodrug converted to active metabolite F-ara-A.
  • Biological description

    DNA synthesis inhibitor. Prodrug converted to active metabolite F-ara-A which inhibits ribonucleotide reductase and competitively inhibits DNA polymerase. Also prevents DNA ligase I from joining DNA. Induces apoptosis. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    21679-14-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Torella D  et al. Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am J Physiol Heart Circ Physiol 292:H2935-43 (2007). Read more (PubMed: 17293493) »
  • Nishioka C  et al. Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway. Leukemia 21:1044-9 (2007). Read more (PubMed: 17344917) »
  • Kano Y  et al. In vitro cytotoxic effects of fludarabine (2-F-ara-A) in combination with commonly used antileukemic agents by isobologram analysis. Leukemia 14:379-88 (2000). Read more (PubMed: 10720130) »

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