Overview

  • Product name

    Fludarabine phosphate, DNA synthesis inhibitor
  • Description

    DNA synthesis inhibitor. Antitumor agent.
  • Biological description

    DNA synthesis inhibitor. Antitumor agent. Interferes with ribonucleotide reductase and DNA polymerase as a purine analogue. Shows antitumor effects in vivo (IC50 = 8-30 μM). Orally active.
  • Purity

    > 98%
  • CAS Number

    75607-67-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(2R,3S,4S,5R)-5-(6-Amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
  • Molecular weight

    365.21
  • Molecular formula

    C10H13FN5O7P
  • PubChem identifier

    30751
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(N=C2N)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sorscher EJ  et al. In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase. Cancer Chemother Pharmacol 70:321-9 (2012). Read more (PubMed: 22760227) »
  • Bagley RG  et al. Bone marrow CFU-GM and human tumor xenograft efficacy of three antitumor nucleoside analogs. Int J Oncol 34:1329-40 (2009). Read more (PubMed: 19360345) »
  • Deharvengt S  et al. Efficient electrogene therapy for pancreatic adenocarcinoma treatment using the bacterial purine nucleoside phosphorylase suicide gene with fludarabine. Int J Oncol 30:1397-406 (2007). Read more (PubMed: 17487360) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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