Overview

  • Product name

    Flumazenil, Benzodiazepine antagonist
  • Description

    Benzodiazepine antagonist
  • Alternative names

    • Ro 15-1788
  • Biological description

    Selective non-competitive benzodiazepine antagonist with low affinity for α4- and α6-subunits
  • Purity

    > 99%
  • CAS Number

    78755-81-4
  • Chemical structure

    Chemical Structure

Properties

Images

  • Inhibition of insulin (1 nM) induced tonic current by flumazenil and zolpidem.

    Effects of flumazenil (1 µM) on the currents in an ACSF (a) and an insulin treated neuron (b).

    (From Figure 2A of Jin et al).

References

This product has been referenced in:

  • Li J  et al. Comparison of in vivo and ex vivo [3H]flumazenil binding assays to determine occupancy at the benzodiazepine binding site of rat brain GABAA receptors. Neuropharmacology 51:168-72 (2006). Read more (PubMed: 16697018) »
  • Atack JR  et al. Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors. Neuropsychopharmacology 20:255-62 (1999). Read more (PubMed: 10063485) »
  • Haefely W The preclinical pharmacology of flumazenil. Eur J Anaesthesiol Suppl 2:25-36 (1988). Read more (PubMed: 2842136) »
See all 3 Publications for this product

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