Overview

  • Product name

    Flumethasone, Glucocorticoid receptor agonist
  • Description

    Glucocorticoid receptor agonist
  • Biological description

    Glucocorticoid receptor agonist. Inhibits platelet-activating factor-induced aggregation. Shows anti-inflammatory, antipruritic and vasoconstrictive effects in vivo.
  • Purity

    > 99%
  • CAS Number

    2135-17-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • Molecular weight

    410.45
  • Molecular formula

    C22H28F2O5
  • PubChem identifier

    16490
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Miolo G  et al. Photoactivation of corticosteroids in UVB-exposed skin. J Photochem Photobiol B 103:35-41 (2011). Read more (PubMed: 21324709) »
  • Malone EM  et al. Development of a rapid method for the analysis of synthetic growth promoters in bovine muscle using liquid chromatography tandem mass spectrometry. Anal Chim Acta 637:112-20 (2009). Read more (PubMed: 19286019) »
  • Zwahlen RD  et al. In vitro aggregation of bovine neonatal neutrophils. A comparative study with adult cattle. Inflammation 14:375-87 (1990). Read more (PubMed: 2379953) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145819.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up