Flunarizine dihydrochloride, dual Na+/Ca2+ channel blocker (ab141798)

Overview

  • Product name

    Flunarizine dihydrochloride, dual Na+/Ca2+ channel blocker
  • Description

    Potent dual Na+/Ca2+ channel blocker
  • Biological description

    Potent dual Na+/Ca2+ channel blocker (IC50 values are 0.4 and 2.2 μM for Na+ and voltage-gated T-type Ca2+ channels respectively). Shows vasodilatory and neuroprotective effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    30484-77-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[Bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine dihydrochloride
  • Molecular weight

    477.40
  • Molecular formula

    C26H26F2N2.2HCl
  • PubChem identifier

    5282407
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 5 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl
  • Source

    Synthetic

  • Research areas

Images

  • Flunarizine dihydrochloride blocks L-type Ca2+ currents in Xenopus oocytes.

    A. Time course of L-type channel (CaV1.2+a2d1+ß1a) activity before and during applications of 10 and 100 µM Flunarizine dihydrochloride (ab141798) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV. Periods of compound application are indicated by the horizontal bars. B. Example of superimposed current traces before and during application of 10 and 100 µM Flunarizine dihydrochloride (taken from the experiment described in A).

References

This product has been referenced in:

  • Urenjak J & Obrenovitch TP Pharmacological modulation of voltage-gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol Rev 48:21-67 (1996). Read more (PubMed: 8685246) »
  • Eichler ME  et al. The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after nerve growth factor deprivation and in vivo after axotomy. J Neurochem 62:2148-57 (1994). Read more (PubMed: 8189223) »
  • De Clerck F & Van Nueten JM Platelet-mediated vascular contractions. Inhibition by flunarizine, a calcium-entry blocker. Biochem Pharmacol 32:765-71 (1983). Read more (PubMed: 6404280) »

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